Hyung Seok Kim^1,#, Ju A Son^2,#, Minji Kang^3,4,#, Soon Sun Kim³, Geum Ok Baek³, Moon Gyeong Yoon³, Se Ha Jang^3,4, Dokyung Jung⁵, Ji Eun Han³, Jae Youn Cheong^3,*, Jung Woo Eun^3,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070392 - 19 January 2026

Abstract Objectives: Early detection of hepatocellular carcinoma (HCC) is a significant challenge due to the limited sensitivity of alpha-fetoprotein (AFP). This study aimed to assess serum-derived extracellular vesicle-encapsulated GULP PTB domain-containing engulfment adaptor 1 (EV-GULP1) as a novel, noninvasive biomarker for HCC detection and prognosis, leveraging the potential of tumor-specific molecules carried by small extracellular vesicles (EVs). Methods: The study utilized both internal and external cohorts of HCC patients and controls. Small EVs were isolated from serum samples, then characterized and validated to confirm their identity. The expression levels of EV-GULP1 were quantified using quantitative reverse transcription… More >

Katerina Ondraskova^1,2, Matous Cwik³, Ondrej Horky⁴, Jitka Berkovcova⁴, Jitka Holcakova¹, Martin Bartosik¹, Tomas Kazda⁵, Klara Mrazova^1,6, Michal Uher⁷, Igor Kiss³, Roman Hrstka^1,3,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070116 - 19 January 2026

Abstract Objectives: Cancer treatment relies heavily on accurate diagnosis and effective monitoring of the disease. These processes often involve invasive procedures, such as colonoscopy, to detect malignant tissues, followed by molecular analyses to determine relevant biomarkers. This study aimed to evaluate the clinical performance of droplet digital PCR (ddPCR) for detecting Kirsten Rat Sarcoma Viral Proto-Oncogene (KRAS), Neuroblastoma RAS Viral Oncogene Homolog (NRAS), and B-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF) mutations in circulating tumor DNA (ctDNA) from colorectal cancer patients using liquid biopsy. Methods: ctDNA was isolated from colorectal cancer (CRC) patients (n = 110) and analyzed for KRAS, BRAF,… More >

Sha Hu^1,2,#, Wenjing Wang^1,#, Qianfang Hu^3,#, Rujuan Zheng^1,2, Qinghe Huang^1,2, Hui Shi^1,2, Xinyuan Ding^3,*, Wenjuan Wang^1,2,*, Zengyan Zhu^1,2,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.068967 - 19 January 2026

Abstract Objectives: Acquired resistance to paclitaxel represents a critical barrier to the effective chemotherapy of non-small cell lung cancer (NSCLC). The present study aimed to elucidate the molecular and pharmacological mechanisms promoting paclitaxel resistance in NSCLC and to explore potential strategies for overcoming this resistance. Methods: Here, we report an integrated pharmacological and analytical approach to quantify paclitaxel disposition and overcome resistance in a A549/TAX cell model (paclitaxel-resistant A549 cells). Results: Cell counting kit-8 (CCK-8) assay, colony formation, and apoptosis assays confirmed that A549/TAX cells exhibited marked resistance to paclitaxel relative to parental A549 cells. Based on… More >

Hameed H. Ahmed¹, Thaer A. Mezher^2,*, Marwan R. Rashid³

Chalcogenide Letters, Vol.22, No.12, pp. 1055-1066, 2025, DOI:10.15251/CL.2025.2212.1055 - 10 December 2025

Abstract Laser ablation in liquids (LAL), a hygienic and effective method for creating high-purity nanomaterials, was used in this study to create cadmium sulfide (CdS) and silver oxide (Ag₂O) nanoparticles. The sputtering process was used to deposit the produced nanomaterials on porous silicon (PSi) substrates, and a number of assays were used to examine the samples’ structural, optical, and electrical characteristics. The CdS sample had a hexagonal crystal structure, according to X-ray diffraction (XRD) data, whereas the AgO sample had a cubic structure. The diameters of the nanoparticles in the two samples ranged from 22.64 nm for… More >

Fengxia Shi¹, Jian Zhao^2,3,*, Xiaodong Dai¹, Guoxin Zhang⁴, Yuan Lu⁴, Yuyan Shang¹

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.12, pp. 2963-2980, 2025, DOI:10.32604/fdmp.2025.073836 - 31 December 2025

Abstract Gas–liquid two-phase jets exhibit markedly enhanced impact performance due to the violent collapse of entrained bubbles, which generates transient microjets and shock waves. The geometry of the nozzle is a decisive factor in controlling jet formation, flow modulation, and impact efficiency. In this work, the structural optimization of gas–liquid two-phase nozzles was investigated numerically using the Volume of Fluid (VOF). Simulation results show that the aero-shaped nozzle delivers a significantly stronger impact on the target surface than conventional geometries. Specifically, its impact pressure is 21% higher than that of a conical straight nozzle and 37%… More > Graphic Abstract

Yang Dou¹, Hao Qin¹, Yuzhi Zhang^1,2, Ning Wang¹, Haiqing Liu^3,4, Wanli Yang^1,2,4,*

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.12, pp. 3091-3122, 2025, DOI:10.32604/fdmp.2025.070082 - 31 December 2025

Abstract In recent years, tuned liquid dampers (TLDs) have emerged as a focal point of research due to their remarkable potential for structural vibration mitigation. Yet, progress in this field remains constrained by an incomplete understanding of the fundamental mechanisms governing sloshing-induced loads in liquid-filled containers. Aqueducts present a distinctive case, as the capacity of their contained water to function effectively as a TLD remains uncertain. To address this gap, the present study investigates the generation mechanisms of sloshing loads under non-resonant cases through a two-dimensional (2D) computational fluid dynamics (CFD) model developed in ANSYS Fluent.… More >

Akramjon Y. Boboev^1,*, Ulugbek R. Karimberdiev¹, Sardor R. Kadirov², Nuritdin Y. Yunusaliyev¹

Chalcogenide Letters, Vol.22, No.11, pp. 951-957, 2025, DOI:10.15251/CL.2025.2211.951

Abstract This paper investigates the possibility of growing solid solutions of the composition (Ge₂)_1−x−y(GaAs_1−δBi_δ)_x(ZnSe)_y on silicon substrates using a germanium (Ge) buffer layer. The optimal conditions for obtaining a structurally high-quality epitaxial layer have been determined. In the study, the solid solution was obtained by liquid-phase epitaxy from a bismuth-containing melt solution. Epitaxial growth was carried out in a palladiumpurified hydrogen atmosphere at a cooling rate of 1 ÷ 1.5°C/min in the temperature range 750 ÷ 650°C. Experimental data showed that the growth of the epitaxial film significantly depends on the size of the gap between the… More >

Yang Dou¹, Hao Qin¹, Yuzhi Zhang^1,2, Ning Wang¹, Haiqing Liu^3,4, Wanli Yang^1,2,4,*

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.11, pp. 2673-2700, 2025, DOI:10.32604/fdmp.2025.069719 - 01 December 2025

Abstract In recent years, tuned liquid dampers (TLDs) have attracted significant research interest; however, overall progress has been limited due to insufficient understanding of the mechanisms governing sloshing-induced loads. In particular, it remains unclear whether the water in aqueducts—common water-diversion structures in many countries—can serve as an effective TLD. This study investigates the generation mechanisms of sloshing loads during the first-order transverse resonance of water in a U-shaped aqueduct using a two-dimensional (2D) numerical model. The results reveal that, at the equilibrium position, the free surface difference between the left and right walls, the horizontal force… More >

Si-Kai Wang¹, Ti-Cai Wang¹, Di-Fei Yi², Jia Rui³, Peng-Fei Cao⁴, Hua-Ping Wang^1,5,*

Structural Durability & Health Monitoring, Vol.19, No.6, pp. 1411-1432, 2025, DOI:10.32604/sdhm.2025.070034 - 17 November 2025

Abstract As a key storage facility, the structural safety of large oil tanks is directly related to the stable operation of the energy system. The static pressure caused by the change of liquid level is one of the main loads in the service process of storage tanks, which determines the structural deformation and damage risk. To explore the structural deformation properties under the change of liquid levels and provide a theoretical basis for the prevention and control of damage risk, this paper systematically analyzes the mechanical response of storage tanks under the pressures induced by different… More > Graphic Abstract

Kui Lin^*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.4, pp. 1-1, 2025, DOI:10.32604/icces.2025.011838

Abstract The phase separation of confined polymeric mixtures plays a critical role in the design of advanced materials and nanoscale devices. Over the past decades, extensive studies have highlighted the interplay of wetting dynamics, hydrodynamics, and interfacial forces in governing phase separation under confinement. In this work [1], we employ molecular dynamics simulations to investigate the dynamics of a binary mixture confined by van der Waals (vdW) walls, revealing a novel phenomenon termed Perpendicular Separation of Two Phases (PSTP). In the initial stage, water molecules residing in the central region rapidly diffuse and condense symmetrically along… More >