SAYUMI TAHARA1, SYDNEY RENTSCH1, FERNANDA COSTAS CASAL DE FARIA1, PATRICIA SARCHET1, ROMA KARNA1, FEDERICA CALORE2,*, RAPHAEL E. POLLOCK1
Oncology Research, Vol.33, No.1, pp. 1-13, 2025, DOI:10.32604/or.2024.053635
- 20 December 2024
Abstract Liposarcoma is one of the most common soft tissue sarcomas, however, its occurrence rate is still rare compared to other cancers. Due to its rarity, in vitro experiments are an essential approach to elucidate liposarcoma pathobiology. Conventional cell culture-based research (2D cell culture) is still playing a pivotal role, while several shortcomings have been recently under discussion. In vivo, mouse models are usually adopted for pre-clinical analyses with expectations to overcome the issues of 2D cell culture. However, they do not fully recapitulate human dedifferentiated liposarcoma (DDLPS) characteristics. Therefore, three-dimensional (3D) culture systems have been the recent… More >
Login
Register
