Warren D. Marcus1,2, Rodger P. McEver3, Cheng Zhu1
Molecular & Cellular Biomechanics, Vol.1, No.4, pp. 245-252, 2004, DOI:10.3970/mcb.2004.001.245
Abstract When a cell adhered to another cell or substratum via surface proteins is forced to detach, lipid membrane tethers are often extruded from the cell surface before the protein bond dissociates. For example, during the inflammatory reaction leukocytes roll on the surface of activated endothelial cells. The rolling adhesion is mediated by interactions of selectins with their ligands, e.g., P-selectin glycoprotein ligand (PSGL)-1, which extrudes membrane tethers from the surfaces of both leukocytes and endothelial cells. Membrane tether extrusion has been suggested to regulate leukocyte rolling. Here we examine several factors that may affect forces… More >
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