Ping Yin*, Wei Wang*, Jian Gao†, Yu Bai*, Zhuo Wang*, Lei Na*, Yu Sun*, Chenghai Zhao*
Oncology Research, Vol.28, No.3, pp. 273-284, 2020, DOI:10.3727/096504020X15783052025051
Abstract Cancer cell stemness is responsible for cancer relapse, distal metastasis, and drug resistance. Here we identified that Frizzled 2 (Fzd2), one member of Wnt receptor Frizzled family, induced human breast cancer (BC)
cell stemness via noncanonical Wnt pathways. Fzd2 was overexpressed in human BC tissues, and Fzd2 overexpression was associated with an unfavorable outcome. Fzd2 knockdown (KD) disturbed the mesenchymallike phenotype, migration, and invasion of BC cells. Moreover, Fzd2 KD impaired BC cell mammosphere
formation, reduced Lgr5+
BC cell subpopulation, and enhanced sensitivity of BC cells to chemical agents.
Mechanistically, Fzd2 modulated and bound with Wnt5a/b and Wnt3 to activate… More >
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