Sukru Gulluoglu*†, Mesut Sahin‡, Emre Can Tuysuz†, Cumhur Kaan Yaltirik§, Aysegul Kuskucu*, Ferda Ozkan¶, Fikrettin Sahin†, Ugur Ture§, Omer Faruk Bayrak*
Oncology Research, Vol.25, No.7, pp. 1177-1188, 2017, DOI:10.3727/096504017X14874349473815
Abstract Chordomas are rare tumors of the spine and skull base that are locally destructive and resistant to chemotherapy
and radiation therapy, with a poor prognosis and limited therapeutic options. Chordoma patients have a long
life expectancy with high mortality from the disease. Cancer stem cells, which are known to exist in chordomas, have extensive proliferative and self-renewal potential and are responsible for maintaining tumor heterogeneity along with chemotherapy and radiotherapy resistance. Leukemia inhibitory factor (LIF) has multiple
functions in stem cell biology, the immune response, and cancer, and is potentially a key molecule that allows… More >
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