Sotirios Charalampos Diamantoudis^1,#,*, Androulla N. Miliotou^2,#, Eleftheria Galatou², Stergiani Telliou³, Konstantinos Sideris⁴, Nikolaos Grigoriadis¹, Ioannis S. Vizirianakis^1,2,*

BIOCELL, Vol.49, No.10, pp. 1799-1858, 2025, DOI:10.32604/biocell.2025.067216 - 22 October 2025

Abstract Hematological cancer stem cells (HCSCs) is a subpopulation of cells within hematological cancers that, through their characteristics, enhance malignancy and render their therapy more challenging. By uncovering the underlying mechanisms behind characteristic properties such as self-renewal, immune evasion, and conventional therapy resistance, as well as the major differences between other cancers and physiological cells, new and alternative targets can be assessed for use in existing and novel immunotherapeutic interventions. Through the evaluation of the existing literature, one can realize that there have already been several studies addressing the use of stem cell transplantation (SCT), monoclonal More > Graphic Abstract

Natalia Lehman, Agnieszka Bojarska-Junak, Michał Zarobkiewicz^*

BIOCELL, Vol.49, No.6, pp. 1085-1099, 2025, DOI:10.32604/biocell.2025.063960 - 24 June 2025

Abstract Introduction: Butyrophilins (BTNs) belong to the immunoglobulin superfamily; they play crucial roles in immune regulation, especially in γδ T cell activation. While their expression has been studied in solid tumours, their involvement in hematologic malignancies remains poorly understood. Objectives: We hypothesised that BTNs are dysregulated in chronic lymphocytic leukaemia (CLL), contributing to γδ T cell dysfunction and potentially influencing disease progression. Methods: In this study, we analyzed publicly available microarray and RNA-seq datasets to investigate the expression patterns of BTN genes in CLL. Results: Our findings reveal significant dysregulation of BTN gene expression in CLL, with BTN2A1, BTN3A1, BTN3A2,… More >

Anuj Sharma¹, Deepak Prashar², Arfat Ahmad Khan³, Faizan Ahmed Khan⁴, Settawit Poochaya^3,*

CMC-Computers, Materials & Continua, Vol.73, No.2, pp. 3629-3648, 2022, DOI:10.32604/cmc.2022.030879 - 16 June 2022

Abstract Leukaemia is a type of blood cancer that is caused by undeveloped White Blood Cells (WBC), and it is also called a blast blood cell. In the marrow of human bones, leukaemia is developed and is responsible for blood cell generation with leukocytes and WBC, and if any cell gets blasted, then it may become a cause of death. Therefore, the diagnosis of leukaemia in its early stages helps greatly in the treatment along with saving human lives. Subsequently, in terms of detection, image segmentation techniques play a vital role, and they turn out to… More >

Torunn O. Apelseth^1,2, Tor Hervig^1,2, Tore Wentzel-Larsen^3,4,5, Kjell Petersen⁶, Håkon Reikvam⁷, Øystein Bruserud^7,8

European Cytokine Network, Vol.22, No.1, pp. 52-62, 2011, DOI:10.1684/ecn.2011.0271

Abstract Background. Platelet concentrates contain soluble mediators derived from both platelets and contaminating leukocytes. During platelet transfusion these mediators are transferred, and transfusion-induced modulation of the cytokine network may then occur, possibly contributing to transfusion reactions, immunomodulation, or affecting residual leukemic cells. In this prospective observational study, we investigate the effect of platelet transfusion on the systemic levels of platelet-derived cytokines, chemokines and interleukins in an unselected group of acute leukaemia patients with severe chemotherapy-induced cytopenia. Study design and methods. We investigated 31 platelet transfusions involving pre-storage, white blood cell-reduced, gamma-irradiated or pathogen-inactivated, photochemically-treated platelet concentrates… More >

Kimberley Joanne Hatfield¹, Siv Lise Bedringsaas², Anita Ryningen³, Bjørn Tore Gjertsen^1,2, Øystein Bruserud^1,2

European Cytokine Network, Vol.21, No.3, pp. 154-164, 2010, DOI:10.1684/ecn.2010.0204

Abstract Introduction. Low oxygen tension is able to modulate the expression of several genes involved in physiological and pathological processes. A major regulator of gene expression is the heterodimeric transcrip tion factor hypoxia inducible factor-1 (HIF-1), which also regulates angiogenesis-related genes, including the protein expression of angioregulatory cytokines. Angiogenesis has been shown to play a role in haematological disorders, and low oxygen tension might thereby influence leukaemogenesis and chemosensitivity in human acute myeloid leukaemia (AML). Methods. We examined the effect of a hypoxic environment (1% O₂) on in vitro-cultured, primary human AML cells with regard to HIF-1α… More >