DONGYUE ZHANG, LINA WANG, HAO WANG, XIAOQIAN LV, QIAN REN, GUOGUANG ZHENG^*

BIOCELL, Vol.45, No.1, pp. 149-156, 2021, DOI:10.32604/biocell.2021.010334 - 26 January 2021

Abstract Legumain is a C13 family cysteine protease. It plays diverse roles under both physiological and pathological conditions. The high-level expression of legumain is detected in solid tumors. Legumain promotes the proliferation and migration of tumor cells. However, the effect of legumain in blood diseases has not been established. In this report, we studied the effect of legumain on leukemia cells by overexpressing it in THP1 cells. The results demonstrated that legumain promoted cell proliferation, whereas it had little effect on cell apoptosis. Furthermore, legumain promoted the migration of THP1 cells. It was worth noting that More >

Fei Meng, Wei Liu

Oncology Research, Vol.23, No.1-2, pp. 7-12, 2015, DOI:10.3727/096504015X14410238486649

Abstract Cervical cancer is the second leading type of cancer in women living in less developed countries. The pathological and molecular mechanisms of cervical cancer are not comprehensively known. Though legumain has been found to be highly expressed in various types of solid tumors, its expression and biological function in cervical cancer remain unknown. In this study, we aimed to investigate legumain expression and functions in cervical cancer. We found that legumain was highly expressed in cervical cancer cells. When knocked down, legumain expression in HeLa and SiHa cells significantly reduced its migration and invasion abilities More >