Mong-Fong Horng^1,#, Thanh-Lam Nguyen^1,#, Thanh-Tuan Nguyen^2,*, Chin-Shiuh Shieh^1,*, Lan-Yuen Guo³, Chen-Fu Hung⁴, Chun-Chih Lo¹

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.075064 - 29 January 2026

Abstract The global population is rapidly expanding, driving an increasing demand for intelligent healthcare systems. Artificial intelligence (AI) applications in remote patient monitoring and diagnosis have achieved remarkable progress and are emerging as a major development trend. Among these applications, mouth motion tracking and mouth-state detection represent an important direction, providing valuable support for diagnosing neuromuscular disorders such as dysphagia, Bell’s palsy, and Parkinson’s disease. In this study, we focus on developing a real-time system capable of monitoring and detecting mouth state that can be efficiently deployed on edge devices. The proposed system integrates the Facial… More >

Xuekun Shao^1,#, Cheng Wang^2,#,*, Mengru Zhang², Yi Wang², Zhuoya Qiu¹, Wen Cai¹, Ruiliang Zhu³, Ping Wang^2,*

BIOCELL, Vol.49, No.11, pp. 2181-2194, 2025, DOI:10.32604/biocell.2025.070859 - 24 November 2025

Abstract Objectives: PI3K plays a pivotal role in the inflammatory response by modulating the production and release of inflammatory factors. Pik3cb is one of the subunits of PI3K, and its specific role in myocardium inflammation remains unelucidated. This study aimed to investigate the role of Pik3cb in the inflammatory response and to elucidate the underlying mechanism. Methods: An inflammation model was established using H9c2 cells treated with LPS and ATP, and Pik3cb expression was evaluated in this model system. Subsequently, an overexpression model was constructed by transfecting cells with a Pik3cb overexpression plasmid, after which the… More > Graphic Abstract

ELMIRA YAKUPOVA¹, VALENTINA BABENKO^1,2, ALEXEY BOCHARNIKOV¹, KSENIYA FEDULOVA¹, DENIS SILACHEV^1,2, EGOR PLOTNIKOV^1,2,*

BIOCELL, Vol.48, No.12, pp. 1827-1834, 2024, DOI:10.32604/biocell.2024.058496 - 30 December 2024

Abstract Background: The active use of stem and progenitor cells in the therapy of various diseases requires the development of approaches for targeted modification of their properties. One such approach is the induction of a pro- or anti-inflammatory phenotype. Methods: In this study, we investigated the effect of a pro-inflammatory environment in vitro on multipotent mesenchymal stromal cells (MSC) by incubation with lipopolysaccharide (LPS). iCELLigence real-time cell analysis system was used for monitoring cell culture growth. Cell energy metabolism was assessed using the Seahorse XFp Analyzer. For the rat stroke experiment, we used a photoinduced thrombosis (PT)… More >

RAN PAN^1,#, JIAYAN MAO^2,#, YUELIANG ZHENG³, WEI CHEN², JUNPING GUO^1,*, LIJUN WANG^3,*

BIOCELL, Vol.48, No.3, pp. 431-441, 2024, DOI:10.32604/biocell.2023.046484 - 15 March 2024

Abstract Background: Sepsis, a type of systemic disease, can impact nearly all organs, tissues and cells. Among them, endothelial cells are amongst the first to be affected and respond to the insult. In this study, we investigated the protective effects of microRNA-30a-5p (miR-30a-5p) on human pulmonary microvascular endothelial cells (HPMECs) treated with lipolysaccharide (LPS). Methods: An in vitro model of sepsis was established in HPMECs with the use of LPS. Transfecting with different tools (mimetic and inhibitor) to modify miR-30a-5p expression. Cell viability, proliferation and apoptosis were detected by the CCK-8 assay, the EdU kit and fluorescence… More >

FARIHA NUSRAT¹, MOHAMMAD TARIQUR RAHMAN², MUHAMMAD MANJURUL KARIM^3,*

BIOCELL, Vol.47, No.1, pp. 81-89, 2023, DOI:10.32604/biocell.2023.024635 - 26 September 2022

Abstract Bacterial endotoxins are a major concern in periodontal health and diseases owing to their structure and biological activity. With up-to-date knowledge of endotoxins and the recent findings about the influence of endotoxins in dental health, their probable mode of pathogenesis, and standard detection methods, this review analyzes the potential efficacy and benefits of probiotics in combination with conventional and contemporary treatment measures. In the oral cavity, Gram-negative bacteria are documented to predominate in the pulpal lesions with radiolucent areas and in the root canal with pulp necrosis, where they pose an absolute threat by promoting… More >

Ping Li^1,2,*, Kewen Zhou^2,*, Jiehao Li², Xiaodan Xu², Ling Wang², Tinghuai Wang²

European Cytokine Network, Vol.33, No.4, pp. 79-89, 2022, DOI:10.1684/ecn.2023.0481

Abstract Background and Objective: Endothelial cell activation plays a critical role in leukocyte recruitment during inflammation and infection. We previously found that cholinergic stimulation (via vagus nerve stimulation) attenuates vascular endothelial impairment and reduces the inflammatory profile in ovariectomized rats. However, the specific molecular mechanism is unclear. This study was designed to explore the effects and molecular mechanisms of cholinergic agonists (acetylcholine [ACh]) on lipopolysaccharide (LPS)-induced endothelial cell activation in vitro. Methods: Human umbilical vein endothelial cells (HUVECs) were treated with different concentrations of LPS (10/100/1000 ng/mL) to activate endothelial cells. HUVECs were untreated, treated with ACh (10^⁻⁵… More >

MEIHUA CHEN^1,2, HUIHUI WANG³, XIAOFENG CHEN^1,2, YAN CHEN^1,2, TIANYING BIAN^1,2,*

BIOCELL, Vol.46, No.10, pp. 2281-2289, 2022, DOI:10.32604/biocell.2022.020697 - 13 June 2022

Abstract Periodontitis is a frequent chronic inflammatory disorder destroying periodontium. Recent studies have revealed the role of bromodomain and extraterminal domain inhibitor (BETi) and microRNA (miR)-130a in regulating macrophage polarization and pro-inflammatory response. However, little is known about whether apabetalone (a novel BETi) and miR-130a are correlated with chronic inflammatory state in periodontitis by regulating macrophage polarization. Here murine RAW264.7 macrophages were applied as an in vitro inflammatory model. After treatment with Porphyromonas gingivalis-derived lipopolysaccharide (Pg LPS) and apabetalone, the expression of macrophage M1 polarization markers and inflammatory cytokines was assessed using real-time PCR, western blot, and enzyme-linked… More >

HAKIM MANGHWAR^1,#,*, AMJAD HUSSAIN^2,#

BIOCELL, Vol.46, No.3, pp. 623-632, 2022, DOI:10.32604/biocell.2022.017316 - 18 November 2021

Abstract Plants are recurrently exposed to myriads of biotic and abiotic stresses leading to several biochemical and physiological variations that cause severe impacts on plant growth and survival. To overcome these challenges, plants activate two primary defense mechanisms, such as structural response (cell wall strengthening and waxy epidermal cuticle development) and metabolic changes, including the synthesis of anti-microbial compounds and proteins, especially the pathogenesis-related (PR) proteins. PR proteins are members of a super large family of defense proteins that exhibit antimicrobial activities. Their over-expression in plants provides tolerance to many abiotic and biotic stresses. PR proteins… More >

SICONG WANG¹, RUIJIN LIU², QIUYUAN HAN², KAIJIANG YU^3,*

BIOCELL, Vol.46, No.1, pp. 149-158, 2022, DOI:10.32604/biocell.2021.013027 - 29 September 2021

Abstract Acute kidney injury (AKI), commonly occurring as complications of sepsis, cardiac surgery, and liver or kidney transplantation, is a critical care syndrome. It is well known that lipopolysaccharide (LPS) shock is a common triggering factor for AKI. This study is aimed to examine the effect of flavonoid compound hispidulin on LPS-induced AKI. For this, renal tubular epithelial cell HK-2 was treated with LPS to establish an in vitro model of AKI. The effect of hispidulin on HK-2 cell viability was examined using CCK-8 assay. Cell apoptosis was determined by TUNEL and flow cytometry. Apoptosis marker proteins… More >

Karen L. Stern¹, Donald Fedrigon III¹, Christopher J. Loftus², Manoj Monga¹

Canadian Journal of Urology, Vol.26, No.2, pp. 9733-9735, 2019

Abstract Introduction: Studies indicate that with a safety wire in the ureter, an increased amount of force is necessary to advance ureteral access sheaths up to the proximal ureter. Theoretically, the compression of the ureter with the wire could lead to an increase in number and severity of ureteral injuries secondary to placement of a sheath. This prospective study aims to evaluate if there is a correlation between the use of a safety wire and ureteral injury from sheath placement by evaluating the location of the wire in relation to the injury after ureteroscopy.
Materials and Methods: Fifty-nine… More >