HAIZHENG LIU1, SHAOFEI CHANG2,*
BIOCELL, Vol.46, No.2, pp. 453-462, 2022, DOI:10.32604/biocell.2021.015340
- 20 October 2021
Abstract Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a phospholipid acyltransferase that promotes
phospholipid synthesis and plasma membrane reconstruction. Exosomes play an important role in tumor metastasis.
The release and uptake of exosomes are key steps of their functions and depend on plasma membrane fusion and
plasma membrane receptors, respectively. The purpose of this study was to explore whether LPCAT1-induced plasma
membrane remodeling would change the secretion and uptake behavior of exosomes in tumor cells. We first
confirmed the abnormally high expression of LPCAT1 in colorectal cancer cells by quantitative real-time PCR (qPCR)
and Western blot analysis. Then,… More >
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