Hui Li*, Zhigang Xiang*, Yan Liu*, Bin Xu*, Jianzhou Tang†
Oncology Research, Vol.25, No.8, pp. 1269-1282, 2017, DOI:10.3727/096504017X14850151453092
Abstract MicroRNAs (miRs), a class of small noncoding RNAs, are key gene regulators through inducing translational
repression or degradation of their target genes. However, the regulatory mechanism of miR-133b underlying
hepatocellular carcinoma (HCC) growth and metastasis remains largely unclear. Here we found that miR-133b
was significantly downregulated in HCC tissues and cell lines. Moreover, low miR-133b levels were significantly associated with the malignant progression of HCC. LASP1, upregulated in HCC tissues and cell lines,
was then identified as a novel target of miR-133b in HCC HepG2 and Hep3B cells. Moreover, the increased
expression of LASP1 was… More >
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