Jiayu Luo^1,#, Jianfeng Liu^1,#, Zuoxiang Sun¹, Pengpeng Shao¹, Danyang Wang², Jianzhong Yao³, Binzhou Li², Lijun Dong¹, Dandan Cao^1,4,*, Jianrong Wei^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2167-2188, 2024, DOI:10.32604/phyton.2024.052858 - 30 September 2024

Abstract Anoplophora glabripennis is one of the most devastating wood-boring beetles that attacks poplars. However, one poplar species, Populus deltoides, has strong resistance to Anoplophora glabripennis infestation, the underlying defense mechanisms against Anoplophora glabripennis are poorly understood. Secondary metabolites play a crucial role in plants to combat biological stress. Here, based on transcriptome and metabolome, we demonstrated that the mechanisms for responses to mechanical damage and insect infestation were different. The degree of reactions to adult groove production, larval incubation, and larval frass production was not identical. In addition, the potential genes with insect resistance activity were identified. Predominant differentially More >

ZHIGUO WANG^1,2,#, KUNLIN LI^2,#, CONGHUA LU², MINGXIA FENG², CAIYU LIN², GUOFANG YIN¹, DAN LUO¹, WENYI LIU³, KAIYU JIN⁴, YUANYAO DOU², DI WU², JIE ZHENG², KEJUN ZHANG⁵, LI LI^2,*, XIANMING FAN^1,*

Oncology Research, Vol.32, No.10, pp. 1637-1648, 2024, DOI:10.32604/or.2024.052664 - 18 September 2024

Abstract Background: Metformin has pleiotropic effects beyond glucose reduction, including tumor inhibition and immune regulation. It enhanced the anti-tumor effects of programmed cell death protein 1 (PD-1) inhibitors in serine/threonine kinase 11 (STK11) mutant non-small cell lung cancer (NSCLC) through an axis inhibition protein 1 (AXIN1)-dependent manner. However, the alterations of tumor metabolism and metabolites upon metformin administration remain unclear. Methods: We performed untargeted metabolomics using liquid chromatography (LC)-mass spectrometry (MS)/MS system and conducted cell experiments to verify the results of bioinformatics analysis. Results: According to the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database, most… More > Graphic Abstract

BEHROOZ JOHARI^1,2,#,*, MILAD PARVINZAD LEILAN^1,#, MAHMOUD GHARBAVI³, YOUSEF MORTAZAVI¹, ALI SHARAFI², HAMED REZAEEJAM⁴

Oncology Research, Vol.32, No.2, pp. 309-323, 2024, DOI:10.32604/or.2023.043576 - 28 December 2023

Abstract The Myc gene is the essential oncogene in triple-negative breast cancer (TNBC). This study investigates the synergistic effects of combining Myc decoy oligodeoxynucleotides-encapsulated niosomes-selenium hybrid nanocarriers with X-irradiation exposure on the MDA-MB-468 cell line. Decoy and scramble ODNs for Myc transcription factor were designed and synthesized based on promoter sequences of the Bcl2 gene. The nanocarriers were synthesized by loading Myc ODNs and selenium into chitosan (Chi-Se-DEC), which was then encapsulated in niosome-nanocarriers (NISM@Chi-Se-DEC). FT-IR, DLS, FESEM, and hemolysis tests were applied to confirm its characterization and physicochemical properties. Moreover, cellular uptake, cellular toxicity, apoptosis, cell More > Graphic Abstract

ROGHAYEH GHORBANI¹, MAHMOUD GHARBAVI², ALI SHARAFI^3,4, ELHAM RISMANI⁵, HAMED REZAEEJAM⁶, YOUSEF MORTAZAVI^1,*, BEHROOZ JOHARI^3,*

Oncology Research, Vol.32, No.1, pp. 101-125, 2024, DOI:10.32604/or.2023.044741 - 15 November 2023

Abstract In the present study, we investigated the synergistic effects of targeted methotrexate-selenium nanostructure containing Myc decoy oligodeoxynucleotides along with X-irradiation exposure as a combination therapy on LNCaP prostate cancer cells. Myc decoy ODNs were designed based on the promoter of Bcl-2 gene and analyzed by molecular docking and molecular dynamics assays. ODNs were loaded on the synthesized Se@BSA@Chi-MTX nanostructure. The physicochemical characteristics of nanostructures were determined by FTIR, DLS, UV-vis, TEM, EDX, in vitro release, and hemolysis tests. Subsequently, the cytotoxicity properties of them with and without X-irradiation were investigated by uptake, MTT, cell cycle, apoptosis, and… More > Graphic Abstract

Yunyun Song¹, Xu Zhang¹, Jialei Yang¹, Zhongqiang Zhang^1,*, Guanggui Cheng¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.25, No.2, pp. 1-1, 2023, DOI:10.32604/icces.2023.09916

Abstract Although floating oil with large particle sizes can easily be separated from water by membrane separation methods, tiny oil droplets with tremendously small volume force and density gradient at oil-water interfaces within water lead to barriers of oil-water separation. Consequently, tiny oil droplets remain in the water, resulting in energy waste, environmental pollution and biological health hazard. Traditional super-wetting membranes with extremely small pore sizes were easily blocked during the oil-water separation process. Inspired by the cactus and rice leaf, we developed a superhydrophobic-superoleophilic surface with conical micro-arrays to realize ultrafast adsorption of tiny oil… More >

LI TIAN^1,#, YONGYI HUANG^1,#, BAOZHEN ZHANG^2,#, YI SONG^1,#, LIN YANG³, QIANQIAN CHEN¹, ZHENG WANG³, YILING WANG¹, QIHAN HE¹, WENHAN YANG¹, SHUYONG YU⁴, TIANYU LU⁵, ZICHEN LIU¹, KAIPING GAO^1,*, XIUJUN FAN^2,*, JIAN SONG^4,*, RIHONG ZHAI^1,*

Oncology Research, Vol.31, No.4, pp. 463-479, 2023, DOI:10.32604/or.2023.028791 - 25 June 2023

Abstract Accumulating evidence has indicated that long non-coding RNAs (lncRNAs) play critical roles in the development and progression of cancers, including esophageal squamous cell carcinoma (ESCC). However, the mechanisms of lncRNAs in ESCC are still incompletely understood and therapeutic attempts for in vivo targeting cancer-associated lncRNA remain a challenge. By RNA-sequencing analysis, we identified that LLNLR-299G3.1 was a novel ESCC-associated lncRNA. LLNLR-299G3.1 was up-regulated in ESCC tissues and cells and promoted ESCC cell proliferation and invasion. Silencing of LLNLR-299G3.1 with ASO (antisense oligonucleotide) resulted in opposite effects. Mechanistically, LLNLR-299G3.1 bound to cancer-associated RNA binding proteins and regulated the expression… More >

G. Manimala^*, A. Chinnasamy

Computer Systems Science and Engineering, Vol.47, No.1, pp. 393-412, 2023, DOI:10.32604/csse.2023.037066 - 26 May 2023

Abstract Cloud computing facilitates the great potentiality of storing and managing remote access to services in terms of software as a service (SaaS). Several organizations have moved towards outsourcing over the cloud to reduce the burden on local resources. In this context, the metaheuristic optimization method is determined to be highly suitable for selecting appropriate services that comply with the requirements of the client’s requests, as the services stored over the cloud are too complex and scalable. To achieve better service composition, the parameters of Quality of Service (QoS) related to each service considered to be… More >

Sait Can Yucebas^*

Intelligent Automation & Soft Computing, Vol.37, No.1, pp. 49-71, 2023, DOI:10.32604/iasc.2023.036871 - 29 April 2023

Abstract The number of studies in the literature that diagnose cancer with machine learning using genome data is quite limited. These studies focus on the prediction performance, and the extraction of genomic factors that cause disease is often overlooked. However, finding underlying genetic causes is very important in terms of early diagnosis, development of diagnostic kits, preventive medicine, etc. The motivation of our study was to diagnose bladder cancer (BCa) based on genetic data and to reveal underlying genetic factors by using machine-learning models. In addition, conducting hyper-parameter optimization to get the best performance from different… More >

Xue Huang^1,*, Zeyu Chen¹, Ruizhao Yang¹, Guangzhu Feng²

Journal of Renewable Materials, Vol.11, No.5, pp. 2301-2319, 2023, DOI:10.32604/jrm.2023.025888 - 13 February 2023

Abstract 1,3-Dioleoyl-2-palmitoylglycerol (OPO) has been a hotspot of functional oils research in recent years, but due to the high cost of sn-1,3 specific lipase in enzymatic synthesis and the lack of biocatalyst stability, large-scale industrial application is difficult. In this study, the prepared magnetic ZnFe₂O₄ was functionalized with dopamine to obtain ZnFe₂O₄@PDA, and the nano-biocatalyst ZnFe₂O₄@PDA@RML was prepared by immobilizing sn-1,3 specific lipase of Rhizomucor miehei lipase (RML) via a cross-linking method. The existence of RML on ZnFe₂O₄@PDA was confirmed by XRD, FTIR, SEM, and TEM. This strategy proved to be simple and effective because the lipase immobilized on… More > Graphic Abstract

Manar Ahmed Hamza^1,*, Shaha Al-Otaibi², Sami Althahabi³, Jaber S. Alzahrani⁴, Abdullah Mohamed⁵, Abdelwahed Motwakel¹, Abu Sarwar Zamani¹, Mohamed I. Eldesouki⁶

Computer Systems Science and Engineering, Vol.46, No.2, pp. 1371-1383, 2023, DOI:10.32604/csse.2023.030232 - 09 February 2023

Abstract Internet of things (IoT) and cloud computing (CC) becomes widespread in different application domains such as business, e-commerce, healthcare, etc. The recent developments of IoT technology have led to an increase in large amounts of data from various sources. In IoT enabled cloud environment, load scheduling remains a challenging process which is applied for ensuring network stability with maximum resource utilization. The load scheduling problem was regarded as an optimization problem that is solved by metaheuristics. In this view, this study develops a new Circle Chaotic Chameleon Swarm Optimization based Load Scheduling (C3SOA-LS) technique for… More >