Guangyu Xu^1,2, Yuxin Liu¹, Bo Yang¹, Siyu Lu^3,*, Chao Liu⁴, Junmin Lyu⁵, Wenfeng Zheng^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.074938 - 29 January 2026

Abstract Soft-tissue motion introduces significant challenges in robotic teleoperation, especially in medical scenarios where precise target tracking is critical. Latency across sensing, computation, and actuation chains leads to degraded tracking performance, particularly around high-acceleration segments and trajectory inflection points. This study investigates machine learning-based predictive compensation for latency mitigation in soft-tissue tracking. Three models—autoregressive (AR), long short-term memory (LSTM), and temporal convolutional network (TCN)—were implemented and evaluated on both synthetic and real datasets. By aligning the prediction horizon with the end-to-end system delay, we demonstrate that prediction-based compensation significantly reduces tracking errors. Among the models, TCN More >

Sarra B. Shakartalla^1,2,3, Iman M. Talaat^1,2,4,*, Nival Ali¹, Shahenaz S. Salih^1,5, Zainab M. Al Shareef^1,2, Noura Alkhayyal⁶, Riyad Bendardaf^2,7,*, Sameh S. M. Soliman^1,8,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070808 - 30 December 2025

Abstract Objectives: Breast cancer (BC) is the leading cause of cancer-related mortality in women, largely due to metastasis. This study aims to explore the role of purine nucleoside phosphorylase (PNP), a key enzyme in purine metabolism, in the aggressiveness and metastatic behavior of BC. Methods: A comprehensive analysis was performed using in silico transcriptomic data (n = 2509 patients), immunohistochemical profiling of BC tissues (n = 103), and validation through western blotting in multiple BC cell lines. Gene expression and survival analyses were conducted using Tumor Immune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis 2 (GEPIA2), and… More >

Kumudesh Mishra^1,2,*, Or Kakhlon^1,2

BIOCELL, Vol.49, No.7, pp. 1101-1123, 2025, DOI:10.32604/biocell.2025.061725 - 25 July 2025

Abstract Mitochondria are central organelles in cellular metabolism, orchestrating energy production, biosynthetic pathways, and signaling networks. Nicotinamide adenine dinucleotide (NAD⁺) and its reduced form (NADH) are essential for mitochondrial metabolism, functioning both as redox coenzymes and as signaling agents that help regulate cellular balance. Thus, while its major role is in energy production, NAD⁺ is widely recognized as a metabolic cofactor and also serves as a substrate for various enzymes involved in cellular signaling, like sirtuins (SIRTs), poly (ADP-ribosyl) polymerases (PARPs), mono (ADP-ribosyl) transferases, and CD38. Sirtuins, a family of NAD⁺-dependent deacetylases, are critical in this regulatory network.… More >

Yuhan Wang, Yimei Meng, Wanqiu Xia, Yusen Liang, Yaru Wang, Peiling Li^*, Lei Fang^*

Oncology Research, Vol.33, No.8, pp. 2141-2159, 2025, DOI:10.32604/or.2025.064367 - 18 July 2025

Abstract Background: Ovarian cancer (OC) is a representative malignancy of the female reproductive system, with a poor prognosis. Long non-coding RNAs (lncRNAs) crucially affect tumor development. This study aimed to identify lncRNAs that potentially participated in OC. Methods: LncRNA expression in cells and tissues was quantified using reverse transcription-quantitative PCR, while fluorescence in situ hybridization determined their cellular localization. Various in vitro assays, together with a mouse xenograft model, were employed to elucidate the function of CYMP antisense RNA 1 (CYMP-AS1) in OC. The molecular mechanisms underlying CYMP-AS1 regulation were investigated through RNA pull-down and immunoprecipitation assays, immunofluorescence… More > Graphic Abstract

CHENG CHENG^1,2,3, CHAO SHI^1,2, SHANG WU^1,2, WEIXING WU³, JINGPING LI^1,2, SINUO GAO^1,2, MENG HAN³, YIMIN WANG³, XIANGMEI ZHANG^2,4,*, YUNJIANG LIU^1,2,*

Oncology Research, Vol.33, No.7, pp. 1633-1648, 2025, DOI:10.32604/or.2025.061637 - 26 June 2025

Abstract Objectives: While programmed cell death 1 (PD-1) inhibitors have improved cancer treatment, the function and mechanisms of programmed cell death ligand 1 (PD-L1), particularly when expressed by cancer cells, remain unclear. This study aims to explore the role of PD-L1 within breast cancer cells and identify key targets for future immunotherapy. Methods: RNA-seq was performed on breast cancer cells with silenced PD-L1 to screen for differentially expressed genes, followed by bioinformatics analysis. Clinical specimens from breast cancer patients undergoing primary surgery without preoperative treatment were collected, along with in vitro analysis to validate the potential mechanism. Results:… More >

Darya Ivashkevich, Arina Ponomarenko^*, Igor Manzhulo, Inessa Dyuizen

BIOCELL, Vol.49, No.4, pp. 607-627, 2025, DOI:10.32604/biocell.2025.061606 - 30 April 2025

Abstract The high prevalence of obesity and associated nonalcoholic fatty liver disease (NAFLD) in the population determines the increased interest in identifying molecular targets for regulating the processes underlying these pathologies. The search for new endogenous bioregulators of lipid metabolism and their inclusion in therapeutic regimens for the treatment of patients is becoming a potentially promising direction in science and medicine. Oleoylethanolamide (OEA) is an endogenous lipid mediator capable of exerting multiple hypolipidemic, anti-inflammatory, and hepatoprotective effects mediated by agonism with receptors of the peroxisome proliferator-activated receptor (PPAR) family (PPAR-α and PPAR-γ). This review focuses on More >

Gege Liu^#, Houfang Zhang^#, Yunhui Peng^*

BIOCELL, Vol.49, No.4, pp. 519-538, 2025, DOI:10.32604/biocell.2025.061470 - 30 April 2025

Abstract Nucleosomes play a vital role in chromatin organization and gene regulation, acting as key hubs that interact with various chromatin-associated factors through diverse binding mechanisms. Recent research has highlighted the prevalence of mutations in linker histones across different types of cancer, emphasizing their critical involvement in cancer progression. These cancer-associated mutations in linker histones have been shown to disrupt nucleosome stacking and the formation of higher-order chromatin structures, which in turn significantly affect epigenetic regulatory processes. In this review, we provide a comprehensive analysis of how cancer-associated linker histone mutations alter their physicochemical properties, influencing More >

Saad Alahmari^1,*, Abdulwhab Alkharashi²

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.1, pp. 849-873, 2025, DOI:10.32604/cmes.2025.062549 - 11 April 2025

Abstract The Internet of Things (IoT) is emerging as an innovative phenomenon concerned with the development of numerous vital applications. With the development of IoT devices, huge amounts of information, including users’ private data, are generated. IoT systems face major security and data privacy challenges owing to their integral features such as scalability, resource constraints, and heterogeneity. These challenges are intensified by the fact that IoT technology frequently gathers and conveys complex data, creating an attractive opportunity for cyberattacks. To address these challenges, artificial intelligence (AI) techniques, such as machine learning (ML) and deep learning (DL),… More >

Jiawei Tian¹, Yu Zhou¹, Lirong Yin^2,*, Salman A. AlQahtani³, Minyi Tang⁴, Siyu Lu⁴, Ruiyang Wang⁴, Wenfeng Zheng^3,4,*

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.2, pp. 973-1019, 2025, DOI:10.32604/cmes.2024.057261 - 27 January 2025

Abstract Force feedback bilateral teleoperation represents a pivotal advancement in control technology, finding widespread application in hazardous material transportation, perilous environments, space and deep-sea exploration, and healthcare domains. This paper traces the evolutionary trajectory of force feedback bilateral teleoperation from its conceptual inception to its current complexity. It elucidates the fundamental principles underpinning interaction forces and tactile exchanges, with a specific emphasis on the crucial role of tactile devices. In this review, a quantitative analysis of force feedback bilateral teleoperation development trends from 2011 to 2024 has been conducted, utilizing published journal article data as the… More >

YUEZHOU ZHANG^1,#, ZHAO ZHANG^2,#, JINXIN DONG¹, CHANGAN LIU^1,*

Oncology Research, Vol.33, No.1, pp. 83-102, 2025, DOI:10.32604/or.2024.055866 - 20 December 2024

Abstract Background: Aberrant expression of RNA-binding proteins (RBPs) has been linked to a variety of diseases, including hematological disorders, cardiovascular diseases, and multiple types of cancer. Heterogeneous nuclear ribonucleoprotein C (HNRNPC), a member belonging to the heterogeneous nuclear ribonucleoprotein (hnRNP) family, plays a pivotal role in nucleic acid metabolism. Previous studies have underscored the significance of HNRNPC in tumorigenesis; however, its specific role in malignant tumor progression remains inadequately characterized. Methods: We leveraged publicly available databases, including The Cancer Genome Atlas (TCGA), to explore the potential involvement of HNRNPC across various cancers. Additionally, we performed experimental… More > Graphic Abstract