Guojie Chen*1, Kai Wang*1, Guoshu Li†1, Leidong Wang‡, Yangyang Xiao§, Bo Chen¶
Oncology Research, Vol.28, No.9, pp. 945-959, 2020, DOI:10.3727/096504021X16328213967104
Abstract Long noncoding RNA LAMTOR5 antisense RNA 1 (LAMTOR5-AS1) has been certified as a risk predictor and
diagnostic biomarker of prostate cancer. However, the expression and exact roles of LAMTOR5-AS1 in nonsmall cell lung cancer (NSCLC) remain unclear. Thus, we measured LAMTOR5-AS1 expression in NSCLC
and gauged its clinical value. The detailed roles and downstream working mechanism of LAMTOR5-AS1 in
NSCLC were comprehensively unraveled. qRT-PCR was applied to measure gene expression. Functionally,
utilizing small interfering RNA, LAMTOR5-AS1 was ablated, and the functional alterations were addressed
by means of different experiments. The targeting activities between LAMTOR5-AS1 and microRNA-506-3p
(miR-506-3p) and between miR-506-3p… More >
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