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  • Open Access

    ARTICLE

    Ketogenic diet with oxyresveratrol and zinc inhibits glioblastoma and restores memory function and motor coordination

    TANVI VIJAY GUJARAN1,#, VIGNESH BALAJI EASWARAN1,#, RUNALI SANKHE1, PUGAZHANDHI BAKTHAVATCHALAM2,3, HERMAN SUNIL DSOUZA4, K. SREEDHARA RANGANATH PAI1,*

    Oncology Research, Vol.33, No.2, pp. 381-395, 2025, DOI:10.32604/or.2024.049538 - 16 January 2025

    Abstract Background: To date, there is no effective cure for the highly malignant brain tumor glioblastoma (GBM). GBM is the most common, aggressive central nervous system tumor (CNS). It commonly originates in glial cells such as microglia, oligodendroglia, astrocytes, or subpopulations of cancer stem cells (CSCs). Glucose plays an important role in the, which energy metabolism of normal and cancer cells, but cancer cells exhibit an increased demand for glucose is required for their differentiation and proliferation. The main aim of this study is to explore the anti-cancer efficacy of the ketogenic diet against GBM. Also,… More >

  • Open Access

    REVIEW

    Ketone bodies and inflammation modulation: A mini-review on ketogenic diet’s potential mechanisms in mood disorders

    YAN ZHENG1,2, SIHUI MA3,4,*, KATSUHIKO SUZUKI4, HISANORI KATO3, HUIJUAN JIA3,*

    BIOCELL, Vol.47, No.8, pp. 1897-1906, 2023, DOI:10.32604/biocell.2023.027632 - 28 August 2023

    Abstract Mental disorders such as depression and anxiety inflict significant burdens on individuals and society. Commonly prescribed treatments often involve cognitive therapy and medications. However, for patients resistant to these conventional methods, alternative therapies like the Ketogenic Diet (KD) offer a promising avenue. KD and its key metabolite, β-hydroxybutyrate (BHB), have been hypothesized to alleviate mental disorders through anti-inflammatory actions, a crucial pathway in the pathophysiology of depression. This mini-review examines 15 clinical trials exploring the influence of KD and BHB on inflammation and their potential roles in managing mental disorders. Both human and animal studies More >

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