WEITAO ZHENG¹, DONG JIANG², SONGEN CHEN¹, MEILING WU¹, BAOQI YAN², JIAHUI ZHAI², YUNQIANG SHI², BIN XIE¹, XINGWANG XIE², KANGHONG HU^1,*, WENXUE MA^3,*

Oncology Research, Vol.32, No.12, pp. 1837-1850, 2024, DOI:10.32604/or.2024.056565 - 13 November 2024

Abstract Objectives: The Kirsten rat sarcoma virus (KRAS) G12D oncogenic mutation poses a significant challenge in treating solid tumors due to the lack of specific and effective therapeutic interventions. This study aims to explore innovative approaches in T cell receptor (TCR) engineering and characterization to target the KRAS G12D_7-16 mutation, providing potential strategies for overcoming this therapeutic challenge. Methods: In this innovative study, we engineered and characterized two T cell receptors (TCRs), KDA11-01 and KDA11-02 with high affinity for the KRAS G12D_7-16 mutation. These TCRs were isolated from tumor-infiltrating lymphocytes (TILs) derived from tumor tissues of patients More >

GERHARD HAMILTON^*, MARIE-THERESE EGGERSTORFER, SANDRA STICKLER

Oncology Research, Vol.32, No.8, pp. 1257-1264, 2024, DOI:10.32604/or.2024.051653 - 17 July 2024

Abstract The Kirsten rat sarcoma virus—son of sevenless 1 (KRAS-SOS1) axis drives tumor growth preferentially in pancreatic, colon, and lung cancer. Now, KRAS G12C mutated tumors can be successfully treated with inhibitors that covalently block the cysteine of the switch II binding pocket of KRAS. However, the range of other KRAS mutations is not amenable to treatment and the G12C-directed agents Sotorasib and Adragrasib show a response rate of only approximately 40%, lasting for a mean period of 8 months. One approach to increase the efficacy of inhibitors is their inclusion into proteolysis-targeting chimeras (PROTACs), which… More > Graphic Abstract

SANDRA STICKLER, BARBARA RATH, GERHARD HAMILTON^*

Oncology Research, Vol.32, No.5, pp. 799-805, 2024, DOI:10.32604/or.2024.045356 - 23 April 2024

Abstract Pancreatic cancer has a dismal prognosis due to late detection and lack of efficient therapies. The Kirsten rat sarcoma virus (KRAS) oncogene is mutated in up to 90% of all pancreatic ductal adenocarcinomas (PDACs) and constitutes an attractive target for therapy. However, the most common KRAS mutations in PDAC are G12D (44%), G12V (34%) and G12R (20%) that are not amenable to treatment by KRAS G12C-directed cysteine-reactive KRAS inhibitors such as Sotorasib and Adagrasib that exhibit clinical efficacy in lung cancer. KRAS G12C mutant pancreatic cancer has been treated with Sotorasib but this mutation is More >

Nawab Hussain^1,*, Saud M. Alsulami¹, Hind Alamri^1,2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.135, No.3, pp. 2617-2648, 2023, DOI:10.32604/cmes.2023.023143 - 23 November 2022

Abstract In this paper, we present the existence and uniqueness of fixed points and common fixed points for Reich and Chatterjea pairs of self-maps in complete metric spaces. Furthermore, we study fixed point theorems for Reich and Chatterjea nonexpansive mappings in a Banach space using the Krasnoselskii-Ishikawa iteration method associated with and consider some applications of our results to prove the existence of solutions for nonlinear integral and nonlinear fractional differential equations. We also establish certain interesting examples to illustrate the usability of our results. More >

Amir Imran Faisal Hamdi, Johnson Stanslas^*

Oncologie, Vol.24, No.2, pp. 185-194, 2022, DOI:10.32604/oncologie.2022.023629 - 29 June 2022

Abstract KRAS mutations are among the most common oncogenic abnormalities in cancer. Until recently, drug discovery pursuing KRAS did not produce therapeutic benefits for patients. Specific KRAS inhibitors, such as sotorasib and adagrasib, which bind covalently to codon 12 of substituted glycine to cysteine residue of the protein (G12C), have been approved by the FDA recently for the treatment of lung cancers. Binding of these drugs to the protein inhibits the activation of the GDP-bound inactive state to the GTP-bound active state. Phase 1/2 trials have shown potential anti-tumor activity, particularly in patients with previously treated More >

D. Vijeswaran^1,*, V. Manikandan²

CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.3, pp. 801-813, 2019, DOI:10.32604/cmes.2019.07793

Abstract In a cyber-physical micro-grid system, wherein the control functions are executed through open communication channel, stability is an important issue owing to the factors related to the time-delay encountered in the data transfer. Transfer of feedback variable as discrete data packets in communication network invariably introduces inevitable time-delays in closed loop control systems. This delay, depending upon the network traffic condition, inherits a time-varying characteristic; nevertheless, it adversely impacts the system performance and stability. The load perturbations in a micro-grid system are considerably influenced by the presence of fluctuating power generators like wind and solar… More >

Xingquan Zhai, Wei Xu

Oncology Research, Vol.26, No.7, pp. 1063-1072, 2018, DOI:10.3727/096504018X15152072098476

Abstract This study aimed to explore the biological functions of long noncoding RNA activated by transforming growth factor-b (lncRNA-ATB) in bladder cancer cells. For the expressions of lncRNA-ATB, miR-126, and KRAS, T24 cells were transfected with their specific vectors/shRNA or mimic/inhibitor. Then cell viability, migration, invasion, and apoptosis as well as the protein levels of apoptosis-related factors and PI3K/AKT and mTOR signal pathways were measured. The relationships of lncRNA-ATB and miR-126 or miR-126 and KRAS were analyzed by Dual-Luciferase Reporter assay. Functional experiments showed that lncRNA-ATB overexpression significantly promoted cell viability, migration, and invasion in T24 More >

Guobao Zhang^a,b, Jing-Jing Xiong^a,b, Yongming Huang^a,b, Yong Lu^a,b,c, Ling Wang^a,b

Intelligent Automation & Soft Computing, Vol.24, No.3, pp. 541-551, 2018, DOI:10.31209/2018.100000021

Abstract This paper investigates the delay-dependent stability problem of recurrent neural networks with time-varying delay. A new and less conservative stability criterion is derived through constructing a new augmented Lyapunov-Krasovskii functional (LKF) and employing the linear matrix inequality method. A new augmented LKF that considers more information of the slope of neuron activation functions is developed for further reducing the conservatism of stability results. To deal with the derivative of the LKF, several commonly used techniques, including the integral inequality, reciprocally convex combination, and free-weighting matrix method, are applied. Moreover, it is found that the obtained More >

V. Venkatachalam^{1, *}, D. Prabhakaran¹

CMES-Computer Modeling in Engineering & Sciences, Vol.114, No.3, pp. 321-334, 2018, DOI:10.3970/cmes.2018.114.321

Abstract This paper presents, using Lyapunov-Krasovskii functional technique combined with reciprocal convex lemma is considered for a networked control temperature control system with additive time-varying-delays. In the stability analysis, a new LK functional is assumed, and take the time-derivative of the (LK) functional, using reciprocal convex combination technique was employed to obtain less conservative stability criteria. Finally, the proposed stability analysis culminates into a stability criterion in the LMI (linear matrix inequalities) framework. The results obtained are in accordance with the theoretically obtained in the temperature control system and they are closer to the standard benchmark More >