RONG LIU^1,#, SHENG LI^2,#, SITU XIONG², FUCUN ZHENG², XIANGPENG ZHAN², JIN ZENG², BIN FU², SONGHUI XU², SHAOXING ZHU^1,*, RU CHEN^1,*

Oncology Research, Vol.32, No.11, pp. 1733-1746, 2024, DOI:10.32604/or.2024.050851 - 16 October 2024

Abstract EVI2A has emerged as a significant biomarker in various diseases; however, its biological role and mechanism in kidney renal clear cell carcinoma (KIRC) remains unexplored. We used TCGA and GEO databases to analyze EVI2A gene expression comprehensively and performed pan-cancer assessments. Clinical relevance was evaluated through Kaplan-Meier analysis and ROC curves. The gene’s immune relevance was explored through analyses of the tumor microenvironment (TME), Tumor Immune Single-cell Hub (TISCH), immune checkpoints, and immunotherapy sensitivity. Our results indicate that EVI2A expression is upregulated in KIRC, showing correlations with tumor grade and T/N/M stage. EVI2A demonstrates high… More >

Rachid Karra^1,*, Abdelatif Maslouhi²

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.7, pp. 1611-1631, 2024, DOI:10.32604/fdmp.2024.048447 - 23 July 2024

Abstract Recent studies have underscored the significance of the capillary fringe in hydrological and biochemical processes. Moreover, its role in shallow waters is expected to be considerable. Traditionally, the study of groundwater flow has centered on unsaturated-saturated zones, often overlooking the impact of the capillary fringe. In this study, we introduce a steady-state two-dimensional model that integrates the capillary fringe into a 2-D numerical solution. Our novel approach employs the potential form of the Richards equation, facilitating the determination of boundaries, pressures, and velocities across different ground surface zones. We utilized a two-dimensional Freefem++ finite element model… More >

KUNLUN LI¹, DANDAN LI², BARBOD HAFEZ^3,*, MOUNIR M. SALEM BEKHIT⁴, YOUSEF A. BIN JARDAN⁴, FARS KAED ALANAZI⁴, EHAB I. TAHA⁴, SAYED H. AUDA⁴, FAIQAH RAMZAN^5,*, MUHAMMAD JAMIL⁶

Oncology Research, Vol.32, No.4, pp. 737-752, 2024, DOI:10.32604/or.2023.042925 - 20 March 2024

Abstract Kidney Renal Clear Cell Carcinoma (KIRC) is a malignant tumor that carries a substantial risk of morbidity and mortality. The MMP family assumes a crucial role in tumor invasion and metastasis. This study aimed to uncover the mechanistic relevance of the MMP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma (KIRC) through a comprehensive approach encompassing both computational and molecular analyses. STRING, Cytoscape, UALCAN, GEPIA, OncoDB, HPA, cBioPortal, GSEA, TIMER, ENCORI, DrugBank, targeted bisulfite sequencing (bisulfite-seq), conventional PCR, Sanger sequencing, and RT-qPCR based analyses were used in the… More >

Mingzhe Huang, Mi Xiao^*, Liang Gao, Mian Zhou, Wei Sha, Jinhao Zhang

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.3, pp. 2479-2505, 2024, DOI:10.32604/cmes.2023.045735 - 11 March 2024

Abstract Cellular thin-shell structures are widely applied in ultralightweight designs due to their high bearing capacity and strength-to-weight ratio. In this paper, a full-scale isogeometric topology optimization (ITO) method based on Kirchhoff–Love shells for designing cellular tshin-shell structures with excellent damage tolerance ability is proposed. This method utilizes high-order continuous nonuniform rational B-splines (NURBS) as basis functions for Kirchhoff–Love shell elements. The geometric and analysis models of thin shells are unified by isogeometric analysis (IGA) to avoid geometric approximation error and improve computational accuracy. The topological configurations of thin-shell structures are described by constructing the effective More >

MUNEEBA MALIK¹, MAMOONA MAQBOOL², TOOBA NISAR³, TAZEEM AKHTER⁴, JAVED AHMED UJAN^5,6, ALANOOD S. ALGARNI⁷, FAKHRIA A. AL JOUFI⁸, SULTAN SHAFI K. ALANAZI⁹, MOHAMMAD HADI ALMOTARED¹⁰, MOUNIR M. SALEM BEKHIT¹¹, MUHAMMAD JAMIL^12,*

Oncology Research, Vol.31, No.6, pp. 899-916, 2023, DOI:10.32604/or.2023.030760 - 15 September 2023

Abstract The low survival rate of Kidney renal clear cell carcinoma (KIRC) patients is largely attributed to cisplatin resistance. Rather than focusing solely on individual proteins, exploring protein-protein interactions could offer greater insight into drug resistance. To this end, a series of in silico and in vitro experiments were conducted to identify hub genes in the intricate network of cisplatin resistance-related genes in KIRC chemotherapy. The genes involved in cisplatin resistance across KIRC were retrieved from the National Center for Biotechnology Information (NCBI) database using search terms as “Kidney renal clear cell carcinoma” and “Cisplatin resistance”. The genes… More >

Hanjiang Chang^1,2,*, Qiang Tian¹, Haiyan Hu¹

CMES-Computer Modeling in Engineering & Sciences, Vol.136, No.1, pp. 825-860, 2023, DOI:10.32604/cmes.2023.022774 - 05 January 2023

Abstract To model a multibody system composed of shell components, a geometrically exact Kirchhoff-Love triangular shell element is proposed. The middle surface of the shell element is described by using the DMS-splines, which can exactly represent arbitrary topology piecewise polynomial triangular surfaces. The proposed shell element employs only nodal displacement and can automatically maintain C¹ continuity properties at the element boundaries. A reproducing DMS-spline kernel skill is also introduced to improve computation stability and accuracy. The proposed triangular shell element based on reproducing kernel DMS-splines can achieve an almost optimal convergent rate. Finally, the proposed shell element More > Graphic Abstract

Peng Yu, Weijing Yun, Junlei Tang, Sheng He^*

CMES-Computer Modeling in Engineering & Sciences, Vol.131, No.2, pp. 949-978, 2022, DOI:10.32604/cmes.2022.018596 - 14 March 2022

Abstract Based on our proposed adaptivity strategy for the vibration of Reissner–Mindlin plate, we develop it to apply for the vibration of Kirchhoff plate. The adaptive algorithm is based on the Geometry-Independent Field approximaTion (GIFT), generalized from Iso-Geometric Analysis (IGA), and it can characterize the geometry of the structure with NURBS (Non-Uniform Rational B-Splines), and independently apply PHT-splines (Polynomial splines over Hierarchical T-meshes) to achieve local refinement in the solution field. The MAC (Modal Assurance Criterion) is improved to locate unique, as well as multiple, modal correspondence between different meshes, in order to deal with error More >

Zhanjun Wu¹, Tengteng Li¹, Jiachen Zhang², Yifan Wu³, Jianle Li¹, Lei Yang¹, Hao Xu^1,*

Structural Durability & Health Monitoring, Vol.16, No.1, pp. 1-14, 2022, DOI:10.32604/sdhm.2022.019554 - 11 February 2022

Abstract Shape sensing as a crucial component of structural health monitoring plays a vital role in real-time actuation and control of smart structures, and monitoring of structural integrity. As a model-based method, the inverse finite element method (iFEM) has been proved to be a valuable shape sensing tool that is suitable for complex structures. In this paper, we propose a novel approach for the shape sensing of thin shell structures with iFEM. Considering the structural form and stress characteristics of thin-walled structure, the error function consists of membrane and bending section strains only which is consistent… More >

Hongwei Guo³, Xiaoying Zhuang^3,4,5, Timon Rabczuk^1,2,*

CMC-Computers, Materials & Continua, Vol.59, No.2, pp. 433-456, 2019, DOI:10.32604/cmc.2019.06660

Abstract In this paper, a deep collocation method (DCM) for thin plate bending problems is proposed. This method takes advantage of computational graphs and backpropagation algorithms involved in deep learning. Besides, the proposed DCM is based on a feedforward deep neural network (DNN) and differs from most previous applications of deep learning for mechanical problems. First, batches of randomly distributed collocation points are initially generated inside the domain and along the boundaries. A loss function is built with the aim that the governing partial differential equations (PDEs) of Kirchhoff plate bending problems, and the boundary/initial conditions More >

Y.C. Cai¹, S.N. Atluri²

CMES-Computer Modeling in Engineering & Sciences, Vol.83, No.3, pp. 249-274, 2012, DOI:10.3970/cmes.2012.083.249

Abstract This paper presents a very simple finite element method for geometrically nonlinear large rotation analyses of plate/shell structures comprising of thin members. A fully nonlinear theory of deformation is employed in the updated Lagrangian reference frame of each plate element, to account for bending, stretching and torsion of each element. An assumed displacement approach, based on the Discrete Kirchhoff Theory (DKT) over each element, is employed to derive an explicit expression for the (18x18) symmetric tangent stiffness matrix of the plate element in the co-rotational reference frame. The finite rotation of the updated Lagrangian reference… More >