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    ARTICLE

    KIF18A is a potential prognostic factor and promotes tumor progression in oral tongue squamous cell carcinoma

    XIAOFEI LV1,#, XI YU2,#, JIE XU3, MINGYI WANG4, CHENG PENG1,*

    BIOCELL, Vol.46, No.5, pp. 1189-1196, 2022, DOI:10.32604/biocell.2022.018249

    Abstract The kinesin family member 18A protein was dysregulated in several human cancers and involved in cancer progression. However, the significance in oral tongue squamous cell carcinoma (OTSCC) has not been studied. The present study was intended to explore the functions of KIF18A in oral tongue squamous cell carcinoma. The immunohistochemistry (IHC) assay was performed to assess the relationships between the KIF18A protein expression level and clinical-pathological features of the patients. The biological functions of KIF18A in OTSCC cells were investigated by the experiments in vitro and in vivo. Based on immunohistochemistry, we found that KIF18A was correlated with the clinical-pathological… More >

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