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    ARTICLE

    Reduced Expression of Jumonji AT-Rich Interactive Domain 2 (JARID2) in Glioma Inhibits Tumor Growth In Vitro and In Vivo

    Zhenjiang Li*1, Chenyang Xu*1, Ming Gao*, Bingqian Ding*, Xinting Wei, Nan Ji

    Oncology Research, Vol.25, No.3, pp. 365-372, 2017, DOI:10.3727/096504016X14738135889976

    Abstract Jumonji AT-rich interactive domain 2 (JARID2) is a member of the Jumonji family of proteins and has been proposed as an oncogene in several types of human cancer. However, the role of JARID2 in human glioma has not yet been understood. The present study was designed to determine the roles of JARID2 in the proliferation and migration in human glioma cells and the growth of glioma cells in nude mice. Our data indicate that JARID2 is upregulated in human glioma tissues and cell lines. Knockdown of JARID2 obviously inhibits the proliferation of U87MG cells and More >

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