Jinhui Wu, Dongshuang Wang
Oncology Research, Vol.25, No.6, pp. 863-871, 2017, DOI:10.3727/096504016X14772315906527
Abstract Chemotherapy is typically used to treat choriocarcinoma. However, a small proportion of this malignancy
develops resistance to common chemotherapeutic drugs such as methotrexate (MTX) and floxuridine (FUDR).
This study aimed to investigate the role and potential mechanisms of chloride intracellular channel protein 1
(CLIC1) in the development of chemoresistance in choriocarcinoma JeG3 cells. Two chemoresistant sublines
were induced from their parental cell line JeG3 through intermittent exposure to MTX (named JeG3/MTX) or
FUDR (named JeG3/FUDR). It was found that expression of CLIC1 was significantly higher in the chemoresistant sublines JeG3/MTX and JeG3/FUDR than in their… More >
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