Yangmei Zhang*1, Xichang Zhou†1, Long Cheng†, Xiang Wang*, Qinglin Zhang‡, Youwei Zhang*, Sanyuan Sun*
Oncology Research, Vol.28, No.3, pp. 213-223, 2020, DOI:10.3727/096504019X15668125347026
Abstract PRKAA1 (protein kinase AMP-activated catalytic subunit 1) is a catalytic subunit of AMP-activated protein
kinase (AMPK), which plays a key role in regulating cellular energy metabolism through phosphorylation,
and genetic variations in the PRKAA1 have been found to be associated with gastric cancer risk. However, the
effect and underlying molecular mechanism of PRKAA1 on gastric cancer tumorigenesis, especially the proliferation and apoptosis, are not fully understood. Our data showed that PRKAA1 is highly expressed in BGC-
823 and MKN45 cells and is expressed low in SGC-7901 and MGC-803 cells in comparison with the other
gastric cancer cells. PRKAA1 downregulation by… More >
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