Vahid Ziaee1,2, Fatemeh Tahghighi1,2, Mohammad Hassan Moradinejad2, Sara Harsini3, Maryam Mahmoudi4, Arezou Rezaei3, Samaneh Soltani5, Maryam Sadr5, Yahya Aghighi6, Nima Rezaei2,3,5
European Cytokine Network, Vol.25, No.2, pp. 35-40, 2014, DOI:10.1684/ecn.2014.0352
Abstract Background: Juvenile systemic lupus erythematosus (JSLE) is a polygenic, autoimmune disorder of
unknown origin. As proinflammatory cytokines, including interleukin-6 (IL-6) and the interleukin-1 (IL-1) family,
seem to contribute to the pathogenesis of JSLE, this investigation was performed to assess the associations of
particular single nucleotide polymorphisms (SNPs) of IL-6 and IL-1 genes in a case-control study. Methods: Fifty
nine JSLE cases were recruited for this study as the patient group, and were compared against 140 healthy, unrelated,
control subjects. Using the polymerase chain reaction with the sequence-specific primer method, genotyping was
carried out for the… More >