Fei Li^*1, Bin Liu^†1, Xiaolan Zhou^*, Quan Xu^‡

Oncology Research, Vol.26, No.9, pp. 1365-1373, 2018, DOI:10.3727/096504018X15154085345907

Abstract DNA damage response induced by ionizing radiation (IR) is an important event involved in the sensitivity and efficiency of radiotherapy in human medulloblastoma. RNF8 is an E3 ubiquitin ligase and has key roles in the process of DNA damage and repair. Our study aimed to evaluate the effect of RNF8 in the DNA damage repair induced by IR exposure in medulloblastoma cells. We found that the levels of RNF8 were significantly upregulated by γ-ray irradiation in a dose-dependent manner in medulloblastoma cells and colocalized with γ-H2AX, a sensitive marker of DNA double-strand breaks induced by… More >

Liang Li^*1, Huijuan Liu^*1, Lianjiang Du^†, Pan Xi^*, Qian Wang^*, Yanqin Li^‡, Di Liu^§

Oncology Research, Vol.26, No.4, pp. 547-556, 2018, DOI:10.3727/096504017X15016337254605

Abstract MicroRNA dysregulation contributes to malignant progression, dissemination, and profound treatment resistance in multiple cancers. miR-449a is recognized as a tumor suppresser. However, the roles of miR-449a in lung cancer initiation and progression are largely unknown. Our study aims to investigate the roles and underlying mechanism of miR-449a in modulating sensitivity to ionizing radiation (IR) in non-small cell lung cancer (NSCLC). Lung cancer cells were transfected with miR-449a mimics or negative control and exposed to IR; the levels of target protein, glycolysis, cell viability, apoptosis, and DNA damage were examined. miR-449a was suppressed in lung cancer… More >

Hai Liu^*, Xuanxuan Wang^*, Aihua Huang^†, Huaping Gao^‡, Yikan Sun^§, Tingting Jiang^*, Liming Shi^*, Xianjie Wu^¶, Qinghua Dong^#, Xiaonan Sun^*

Oncology Research, Vol.27, No.1, pp. 29-38, 2019, DOI:10.3727/096504018X15179694020751

Abstract Artemis is a key protein of NHEJ (nonhomologous end joining), which is the major pathway for the repair of IR-induced DSBs in mammalian cells. However, the expression of Artemis in tumors and the influence of silencing Artemis on tumor sensitivity to radiation have not been investigated fully. In this study, we investigated how the expression levels of Artemis may affect the treatment outcome of radiotherapy and chemotherapy in colorectal cancer cells. First, we found that the expression of Artemis is strong in some human rectal cancer samples, being higher than in adjacent normal tissues using… More >

BING WANG^*, KAORU TANAKA, KOUICHI MARUYAMA, YASUHARA NINOMIYA, TAKANORI KATSUBE, MITSURU NENOI^*

BIOCELL, Vol.46, No.10, pp. 2315-2325, 2022, DOI:10.32604/biocell.2022.021161

Abstract Investigation on possible induction of adaptive response (AR) by high-liner energy transfer (LET) particle radiation for protection against low-LET photon radiation-induced detrimental effects has not yet been performed in utero. This study verified if an AR could be induced by high-LET particle radiation from accelerated heavy ions against low-LET X-ray radiation-induced detrimental effects on fetal mice. Total body irradiation of pregnant C57BL/6J mice were performed by delivering a priming dose ranging from 10 mGy to 320 mGy of particle radiation on gestation day 11 followed one day later by a challenge dose at 3500 mGy from… More >

Svetla P. Gateva^1,*, Gabriele Jovtchev¹, Tsveta V. Angelova¹, Tzvetana P. Nonova², Nikolay Tyutyundzhiev³, Elena G. Geleva², Kostadin Katrandzhiev¹, Nina A. Nikolova², Dimitar Dimitrov⁴, Christo V. Angelov²

Phyton-International Journal of Experimental Botany, Vol.91, No.2, pp. 293-313, 2022, DOI:10.32604/phyton.2022.016397

Abstract Plants in natural ecosystems are exposed to a combination of UV radiation, ionizing radiation (IR) and other abiotic factors. These factors change with the altitude. We investigated DNA alterations of some wild plants of different plant families in natural ecosystems at three altitudes in Rila Mountain, Bulgaria (1500, 1782, and 2925 m above sea level (a.s.l.) exposed to UV radiation, IR and other abiotic stresses, to assess the tolerance of plant species to the changing environmental conditions in three successive growth seasons. For this purpose, physicochemical, cytogenetic, and molecular methods were applied. DNA damage was assessed… More >

Alireza Mohammadkarim¹, Manijhe Mokhtari-Dizaji^2,*, Ali Kazemian³, Hazhir Saberi⁴, Mohammad Mehdi Khani⁵, Mohsen Bakhshandeh⁶

Molecular & Cellular Biomechanics, Vol.16, No.4, pp. 275-287, 2019, DOI:10.32604/mcb.2019.06280

Abstract The mechanical properties of living cells are known to be promising biomarkers when investigating the health and functions of the human body. Ionizing irradiation results in vascular injury due to endothelial damage. Thus, the current study objective was to evaluate the influence of continuous radiation doses on the mechanical properties of human umbilical vein endothelial cells (HUVECs), and to identify Young’s modulus (E) and viscoelastic behavior. Single-dose (0, 2, 4, 6, and 8 Gy) radiation was applied to HUVECs using a Cobalt-60 treatment machine in the current vitro irradiation study. Thereafter, a micropipette-aspiration technique was… More >