Anne Riemann*, Antje Güttler†, Verena Haupt*, Henri Wichmann†, Sarah Reime*, Matthias Bache†, Dirk Vordermark†, Oliver Thews*
Oncology Research, Vol.26, No.2, pp. 191-200, 2018, DOI:10.3727/096504017X14965111926391
Abstract Carbonic anhydrase (CA) IX has emerged as a promising target for cancer therapy. It is highly upregulated in
hypoxic regions and mediates pH regulation critical for tumor cell survival as well as extracellular acidification of the tumor microenvironment, which promotes tumor aggressiveness via various mechanisms, such as
augmenting metastatic potential. Therefore, the aim of this study was to analyze the complex interdependency
between CA IX and the tumor microenvironment in prostate tumor cells with regard to potential therapeutic
implications. CA IX was upregulated by hypoxia as well as acidosis in prostate cancer cells. This induction… More >
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