Fei Liu*1, Bihua Lin*1, Xin Liu*, Wenzhang Zhang*, Erying Zhang*, Liang Hu*, Yuefan Ma*, Xiangyong Li*, Xudong Tang*†
Oncology Research, Vol.23, No.3, pp. 109-118, 2015, DOI:10.3727/096504015X14496932933610
Abstract Extracellular signal-regulated kinase (ERK)1/2 signaling pathway plays a critical role in regulating tumor
angiogenesis. Our previous studies have demonstrated that HPV-16 oncoproteins enhanced hypoxia-inducible
factor-1α (HIF-1α) protein accumulation and vascular endothelial growth factor (VEGF) and interleukin-8
(IL-8) expression in non-small cell lung cancer (NSCLC) cells, thus contributing to angiogenesis. In this
study, we further investigated the role of ERK1/2 signaling pathway in HPV-16 oncoprotein-induced HIF-1α,
VEGF, and IL-8 expression and in vitro angiogenesis in NSCLC cells. Our results showed that HPV-16 E6 and
HPV-16 E7 oncoproteins promoted the activation of ERK1/2 signaling pathway in A549 More >
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