Liping Xue*1, Bin Lu†1, Bibo Gao‡, Yangyang Shi‡, Jingqi Xu‡, Rui Yang‡, Bo Xu‡, Peng Ding‡
Oncology Research, Vol.27, No.5, pp. 557-564, 2019, DOI:10.3727/096504018X15264647024196
Abstract Because of the characteristics of high invasiveness, relapse, and poor prognosis, the management of malignant
gliomas has always been a great challenge. Nod-like receptor (NLR) family pyrin domain containing 3 (NLRP3) is
a crucial component of the NLRP3 inflammasome, a multiprotein complex that can trigger caspase 1/interleukin-1
(IL-1)-mediated inflammatory response once activated and participates in the pathogeny of diverse inflammatory
diseases as well as cancers. We examined the function of NLRP3 in the development of glioma. Glioma cells were
treated with NLRP3 interference or overexpression vectors, recombinant IL-1 , IL-1 antibody, and NF- B inhibitor.… More >
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