Hongtao Ren*, Zhongwei Wang*, Shuqun Zhang*, Hongbing Ma*, Yali Wang*, Lijun Jia*, Yiming Li†
Oncology Research, Vol.23, No.5, pp. 249-256, 2015, DOI:10.3727/096504016X14562725373716
Abstract Interleukin-17A (IL-17A) plays a significant role in many inflammatory diseases and cancers. The aim of this
study is to investigate the effect of IL-17A on the invasiveness of colorectal cancer. In the study, we found that
IL-17A could promote the migration and invasion of colorectal cancer cells. Furthermore, after being treated
with IL-17A, the expression and activity of matrix metalloproteinase 2 (MMP-2) and MMP-9 were upregulated.
Moreover, the nuclear/overall fractions and DNA-binding activity of p65 and p50 were dramatically elevated by
IL-17A. Pretreatment with a nuclear factor-kB (NF-kB) inhibitor (PDTC) or PI3K/AKT inhibitor (LY294002)
was More >
Login
Register
