Yang Zhao, Wenxia Chen, Weiliang Zhu, Hui Meng, Jie Chen, Jian Zhang
Oncology Research, Vol.25, No.4, pp. 511-522, 2017, DOI:10.3727/096504016X14756226781802
Abstract The purpose of this study was to identify the role of interferon regulatory factor 7 (IRF7) in the bone metastasis
of prostate cancer. Herein we demonstrated the lower expression of IRF7 in bone metastases of prostate cancer.
Overexpression of IRF7 in prostate cancer cells had a marked effect on inhibiting bone metastases but not on
tumor growth in xenograft nude mice. While in vitro, upregulation of IRF7 had little effect on the malignant
phenotype of prostate cancer cells including proliferation, apoptosis, migration, and invasion. However, prostate cancer cells overexpressing IRF7 significantly enhanced the activity of More >
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