MOHD ATHAR^1,*, ANU MANHAS², NISARG RANA², AHMAD IRFAN³

BIOCELL, Vol.48, No.6, pp. 935-944, 2024, DOI:10.32604/biocell.2024.049891

Abstract Computational methods have significantly transformed biomedical research, offering a comprehensive exploration of disease mechanisms and molecular protein functions. This article reviews a spectrum of computational tools and network analysis databases that play a crucial role in identifying potential interactions and signaling networks contributing to the onset of disease states. The utilization of protein/gene interaction and genetic variation databases, coupled with pathway analysis can facilitate the identification of potential drug targets. By bridging the gap between molecular-level information and disease understanding, this review contributes insights into the impactful utilization of computational methods, paving the way for More >

Xiaorui Cui¹, Shan Wang^2,*

International Journal of Mental Health Promotion, Vol.26, No.5, pp. 407-416, 2024, DOI:10.32604/ijmhp.2023.030135

Abstract Research motivation: Through the 12 weeks dance therapy intervention for children with autism, the purpose is to explore the intervention model of dance therapy for children with autism and the changes in motor ability, social ability, and communication ability of children with autism after dance therapy intervention. The results of the research are expected to expand the intervention mode of dance therapy in my country and provide practical reference for rehabilitation intervention of children with autism. Research methods: 24 autistic boys aged 6 to 12 with mild to moderate symptoms were recruited and screened through the Internet… More >

Vinitha Richard, Rajesh Raju, Aswathy Mary Paul, Reshmi Girijadevi, Thankayyan Retnabai Santhosh Kumar, Madhavan Radhakrishna Pillai

Oncology Research, Vol.26, No.1, pp. 17-26, 2018, DOI:10.3727/096504017X14881490607028

Abstract This study is an integrated analysis of the transcriptome profile microRNA (miRNA) and its experimentally validated mRNA targets differentially expressed in the tumorigenic stem-like fraction of oral squamous cell carcinoma (OSCC). We had previously reported the coexistence of multiple drug-resistant tumorigenic fractions, termed side population (SP1, SP2, and MP2), and a nontumorigenic fraction, termed main population (MP1), in oral cancer. These fractions displayed a self-renewal, regenerative potential and expressed known stemness-related cell surface markers despite functional differences. Flow cytometrically sorted pure fractions of SP1 and MP1 cells were subjected to differential expression analysis of both… More >

Daisuke Ishihara^*, Syunnosuke Nozaki, Tomoya Niho, Naoto Takayama

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.2, pp. 1371-1386, 2024, DOI:10.32604/cmes.2024.049694

Abstract The inverse and direct piezoelectric and circuit coupling are widely observed in advanced electro-mechanical systems such as piezoelectric energy harvesters. Existing strongly coupled analysis methods based on direct numerical modeling for this phenomenon can be classified into partitioned or monolithic formulations. Each formulation has its advantages and disadvantages, and the choice depends on the characteristics of each coupled problem. This study proposes a new option: a coupled analysis strategy that combines the best features of the existing formulations, namely, the hybrid partitioned-monolithic method. The analysis of inverse piezoelectricity and the monolithic analysis of direct piezoelectric More >

Mingjian Li, Ping Yang^*, Pengyang Zhao

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.2, pp. 2019-2034, 2024, DOI:10.32604/cmes.2024.048334

Abstract The experimental results in previous studies have indicated that during the ductile fracture of pure metals, vacancies aggregate and form voids at grain boundaries. However, the physical mechanism underlying this phenomenon remains not fully understood. This study derives the equilibrium distribution of vacancies analytically by following thermodynamics and the micromechanics of crystal defects. This derivation suggests that vacancies cluster in regions under hydrostatic compression to minimize the elastic strain energy. Subsequently, a finite element model is developed for examining more general scenarios of interaction between vacancies and grain boundaries. This model is first verified and More >

Jiakai Li, Jianpeng Hu^*, Geng Zhang

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2481-2503, 2024, DOI:10.32604/cmc.2024.050005

Abstract In the process of constructing domain-specific knowledge graphs, the task of relational triple extraction plays a critical role in transforming unstructured text into structured information. Existing relational triple extraction models face multiple challenges when processing domain-specific data, including insufficient utilization of semantic interaction information between entities and relations, difficulties in handling challenging samples, and the scarcity of domain-specific datasets. To address these issues, our study introduces three innovative components: Relation semantic enhancement, data augmentation, and a voting strategy, all designed to significantly improve the model’s performance in tackling domain-specific relational triple extraction tasks. We first… More >

Chanho Park¹, Takefumi Ogawa^2,*

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 3047-3065, 2024, DOI:10.32604/cmc.2024.048901

Abstract Six degrees of freedom (6DoF) input interfaces are essential for manipulating virtual objects through translation or rotation in three-dimensional (3D) space. A traditional outside-in tracking controller requires the installation of expensive hardware in advance. While inside-out tracking controllers have been proposed, they often suffer from limitations such as interaction limited to the tracking range of the sensor (e.g., a sensor on the head-mounted display (HMD)) or the need for pose value modification to function as an input interface (e.g., a sensor on the controller). This study investigates 6DoF pose estimation methods without restricting the tracking… More >

Hayder Kareem Sakran^1,2, Mohd Sharizal Abdul Aziz^1,*, Chu Yee Khor³

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 109-137, 2024, DOI:10.32604/cmes.2024.047245

Abstract The centrifugal pump is a prevalent power equipment widely used in different engineering patterns, and the impeller blade wrap angle significantly impacts its performance. A numerical investigation was conducted to analyze the influence of the blade wrap angle on flow characteristics and energy distribution of a centrifugal pump evaluated as a low specific speed with a value of 69. This study investigates six impeller models that possess varying blade wrap angles (95°, 105°, 115°, 125°, 135°, and 145°) that were created while maintaining the same volute and other geometrical characteristics. The investigation of energy loss… More > Graphic Abstract

JEEMOL. P. A¹, SURESH MATHEW¹, REGHUNADHAN NAIR C.P.^2,*

Journal of Polymer Materials, Vol.39, No.1-2, pp. 111-120, 2022, DOI:10.32381/JPM.2022.39.1-2.7

Abstract Polyether telechelics based on ethylene glycol,1,2-propylene glycol and 1,4- butylene glycol of with various molar masses and bearing at both terminals functional groups such as maleimide, itaconimide, nadimide and hydroxyl groups were individually examined as toughening agents for an unsaturated polyester resin (UPER). For a given telechelic, the toughening effect was evaluated at different mass ratios. The difference in toughening efficacy arose from the differential reactivity of the telechelics end groups combined with the unsaturation of the UPER with the reactive diluent, styrene. This causes a differential distribution of the polyether groups in the UPER… More >

Awais Ahmad¹, Sohail Jabbar^1,*, Sheeraz Akram¹, Anand Paul², Umar Raza³, Nuha Mohammed Alshuqayran¹

CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 3129-3150, 2024, DOI:10.32604/cmc.2024.045385

Abstract This paper presents an innovative approach to enhance the querying capability of ChatGPT, a conversational artificial intelligence model, by incorporating voice-based interaction and a convolutional neural network (CNN)-based impaired vision detection model. The proposed system aims to improve user experience and accessibility by allowing users to interact with ChatGPT using voice commands. Additionally, a CNN-based model is employed to detect impairments in user vision, enabling the system to adapt its responses and provide appropriate assistance. This research tackles head-on the challenges of user experience and inclusivity in artificial intelligence (AI). It underscores our commitment to… More >