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  • Open Access

    COMMENTARY

    A commentary on the interplay of biomaterials and cell adhesion: new insights in bone tissue regeneration

    A. NOEL GRAVINA1,2, NOELIA D´ELÍA1,2, LUCIANO A. BENEDINI2,3,*, PAULA MESSINA1,2

    BIOCELL, Vol.48, No.11, pp. 1517-1520, 2024, DOI:10.32604/biocell.2024.055513 - 07 November 2024

    Abstract This article navigates the relationship between biomaterials and osteogenic cell adhesion, highlighting the importance of mimicking the physiological response for bone tissue regeneration. Within this spirit is an initial description of the interaction between osteoblasts and osteoprogenitor cells with the extracellular matrix, explaining the leading role of integrins and cadherins in cell adhesion, and the intracellular signaling pathways elicited. Additionally, there is a focus on the strategies of advanced biomaterials that foster osteogenesis by replicating the native environment, taking advantage of these known specific signaling pathways. The final remarks lay on the need for careful More >

  • Open Access

    REVIEW

    Visualization of integrin molecules by fluorescence imaging and techniques

    CHEN CAI1, HAO SUN2, LIANG HU3, ZHICHAO FAN1,*

    BIOCELL, Vol.45, No.2, pp. 229-257, 2021, DOI:10.32604/biocell.2021.014338 - 19 February 2021

    Abstract Integrin molecules are transmembrane αβ heterodimers involved in cell adhesion, trafficking, and signaling. Upon activation, integrins undergo dynamic conformational changes that regulate their affinity to ligands. The physiological functions and activation mechanisms of integrins have been heavily discussed in previous studies and reviews, but the fluorescence imaging techniques –which are powerful tools for biological studies– have not. Here we review the fluorescence labeling methods, imaging techniques, as well as Förster resonance energy transfer assays used to study integrin expression, localization, activation, and functions. More >

  • Open Access

    ARTICLE

    Structural Basis of Stress Concentration in the Cytoskeleton

    Ning Wang*

    Molecular & Cellular Biomechanics, Vol.7, No.1, pp. 33-44, 2010, DOI:10.3970/mcb.2010.007.033

    Abstract Professor Y.C. Fung has shown that living tissues remodel extensively in response to mechanical forces such as blood pressure variations. At the cellular level, those mechanical perturbations must be perceived by individual cells. However, mechanisms of mechanochemical transduction in living cells remain a central challenge to cell biologists. Contrary to predictions by existing models of living cells, we reported previously that a local stress, applied via integrin receptors, is propagated to remote sites in the cytoplasm and is concentrated at discrete foci. Here we report that these foci of strains and stresses in the cytoplasm More >

  • Open Access

    ARTICLE

    Kinetics Analysis of Binding between Melanoma Cells and Neutrophils

    Meghan H. Hoskins*, Cheng Dong∗,†

    Molecular & Cellular Biomechanics, Vol.3, No.2, pp. 79-88, 2006, DOI:10.3970/mcb.2006.003.079

    Abstract It has been determined previously that polymorphonuclear leukocytes, or PMNs, can facilitate melanoma cell extravasation through the endothelium under shear conditions [1,2]. The interactions between melanoma cells and PMNs are mediated by the β2-integrins expressed by PMNs and intercellular adhesion molecules (ICAM-1) expressed on melanoma cells. In this study, the kinetics of these interactions was studied using a parallel plate flow chamber. The dissociation rates were calculated under low force conditions for ICAM-1 interactions with both β2-integrins, LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18), together and separately by using functional blocking antibodies on PMNs. The kinetics of PMNs More >

  • Open Access

    ARTICLE

    The Mechanochemical Basis of Cell and Tissue Regulation

    D.E. Ingber1

    Molecular & Cellular Biomechanics, Vol.1, No.1, pp. 53-68, 2004, DOI:10.3970/mcb.2004.001.053

    Abstract This article is a summary of a lecture presented at a symposium on "Mechanics and Chemistry of Biosystems'' in honor of Professor Y.C. Fung that convened at the University of California, Irvine in February 2004. The article reviews work from our laboratory that focuses on the mechanism by which mechanical and chemical signals interplay to control how individual cells decide whether to grow, differentiate, move, or die, and thereby promote pattern formation during tissue morphogenesis. Pursuit of this challenge has required development and application of new microtechnologies, theoretical formulations, computational models and bioinformatics tools. These… More >

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