Tinghui Jiang*, Mengfan Li†, Qiuyin Li‡, Zhiqiang Guo§, Xianjun Sun‡, Xufeng Zhang§, Yan Liu‡, Wenyi Yao‡, Ping Xiao*
Oncology Research, Vol.25, No.7, pp. 1117-1127, 2017, DOI:10.3727/096504016X14821952695683
Abstract Some microRNAs (miRs) have been demonstrated to play promoting or tumor-suppressing roles in the development and progression of hepatocellular carcinoma (HCC). However, the regulatory mechanism of miR-98-5p
in HCC still remains largely unclear. In the present study, our data showed that miR-98-5p was significantly
downregulated in 84 cases of HCC tissues compared to the matched adjacent nontumor tissues. In addition,
downregulation of miR-98-5p was associated with tumor size, portal vein tumor embolus, node metastasis,
and clinical stage in HCC. HCC patients with low expression of miR-98-5p showed a shorter survival time
compared with those with… More >
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