Haiyang Wang*, Chongyang Tang*, Meng Na*, Wei Ma*, Zhenfeng Jiang*, Yifei Gu*, Guizhen Ma†, Haitao Ge*, Hong Shen*, Zhiguo Lin*
Oncology Research, Vol.25, No.2, pp. 187-194, 2017, DOI:10.3727/096504016X14732772150389
Abstract Glioma is a common type of malignant brain tumor characterized by aggressive metastasis capability. Recent
evidence has suggested that noncoding RNAs, including microRNAs, have important functions in the
pathophysiology of glioma development. In this study, we investigated the biological function of miR-422a
in human glioma. We found that miR-422a was downregulated in glioma tissues. We also demonstrated that
expression of miR-422a in glioma cells markedly suppressed cell proliferation, migration, and invasion. In
addition, we identified insulin-like growth factor 1 (IGF1) and IGF1 receptor (IGF1R) as inhibitory targets of
miR-422a in glioma cells. We established that More >
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