Meng Yang*, Xu Zhai†, Tingting Ge*, Chang Yang*, Ge Lou*
Oncology Research, Vol.26, No.5, pp. 703-712, 2018, DOI:10.3727/096504017X14982569377511
Abstract Expression of miR-181a-5p associates with the proliferation and progression of cancer cells via its targets.
This study was designed to investigate the effect of miR-181a-5p and its target inositol polyphosphate-5-
phosphatase A (INPP5A) on the progression of cervical cancers. Upregulation of miR-181a-5p was revealed in
the cervical cancer cell lines HeLa and SiHa in comparison with a normal cervical epithelium cell line End1/
E6E7 (p<0.001). The inhibition and upregulation of miR-181a-5p in cervical cancer cell lines significantly
reduced or increased cell proliferation and invasion capacity, accompanied with enhanced or reduced apoptosis
(p<0.05). Moreover, INPP5A overexpression significantly More >
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