Siddharta Saxena, Vikas Kumar Panwar,^*, Ankur Mittal, Mohammed Taher Mujahid, Mehul Agarwal, Nalin Kumar Srivastav

Canadian Journal of Urology, Vol.32, No.6, pp. 677-683, 2025, DOI:10.32604/cju.2025.063597 - 30 December 2025

Abstract Background: Injuries to the penis resulting from self-inflicted strangulation with various objects are uncommon, yet these injuries are more frequently observed in young adults. Medical literature has identified items such as hair, thread, rubber bands, metallic rings, and vacuum erection devices as tools used for this purpose. These constrictive items impede venous return from the penis, potentially leading to severe complications such as ischemia or necrosis. This case series aims to analyse the clinical presentation, management strategies, and psychological dimensions of self-inflicted penile strangulation through a case series. Case Presentation: We conducted a retrospective analysis of… More >

Yang He^1,#, Tao Xu^2,#, Jian Yang³, Shuang Li⁴, Yiqian Xie⁵, Wenqin Chen^6,7,*, Dong Wang^8,*

Journal of Psychology in Africa, Vol.35, No.6, pp. 731-738, 2025, DOI:10.32604/jpa.2025.074914 - 30 December 2025

Abstract We examined positive coping styles and loneliness effects on the relationship between social anxiety and non-suicidal self-injury (NSSI) behaviors among young adults. A sample of 1129 Chinese college students (females = 42.52%; mean age = 20.00 years, SD = 1.61 years; 53.32% from rural areas) completed the Chinese Revised Social Anxiety Scale for Adolescents (SAS-A), the UCLA Loneliness Scale (ULS-6), the Simplified Coping Style Questionnaire (SCSQ), and the Adolescent Non-suicidal Self-injury Assessment Questionnaire (ANSSIAQ). Controlling for gender, age, onlychild status, and residence, regression analysis revealed that social anxiety is associated with higher levels of NSSI More >

Jung-Yeon Kim^#, Min Hui Park^#, Kiryeong Kim, Jaechan Leem^*

BIOCELL, Vol.49, No.11, pp. 2147-2166, 2025, DOI:10.32604/biocell.2025.070188 - 24 November 2025

Abstract Background: Cisplatin (CDDP) is a cornerstone chemotherapeutic agent for many solid tumors, but its clinical use is severely limited by dose-dependent nephrotoxicity, which results in acute kidney injury (AKI) in a significant proportion of patients. CDDP-induced AKI involves interconnected mechanisms, including inflammation, oxidative stress, and tubular cell death. In this study, we aimed to investigate the renoprotective effects of esculetin (ES), a natural antioxidant coumarin, in a murine model of CDDP-induced AKI. Methods: Male C57BL/6 mice (8–10 weeks) received a single intraperitoneal injection of CDDP (20 mg/kg) with or without ES (40 mg/kg/day, oral gavage).… More >

Raidizon Mercedes, Eric Eidelman, Michael Mawhorter, Max Yudovich, Alireza Aminsharifi^*

Canadian Journal of Urology, Vol.32, No.5, pp. 515-520, 2025, DOI:10.32604/cju.2025.067973 - 30 October 2025

Abstract Background: Spontaneous rupture of the urinary bladder (SRUB) is a rare condition characterized by bladder rupture without any trauma or previous instrumentation. Diagnosing SRUB can be challenging, leading to potential delays in treatment and significant morbidity. Case description: We present a case of a 75-year-old male with a complex medical history, including atrial fibrillation, systemic lupus erythematosus, antiphospholipid syndrome, and chronic anticoagulation, who developed sudden onset gross hematuria and abdominal pain following bilateral internal iliac artery angioembolization for a spontaneous pelvic hematoma in the setting of supratherapeutic anticoagulation. Extraperitoneal bladder perforation was confirmed by CT cystogram.… More >

Wei Hu¹, Dan Xiong^2,*

BIOCELL, Vol.49, No.9, pp. 1711-1731, 2025, DOI:10.32604/biocell.2025.067670 - 25 September 2025

Abstract Objectives: Podocytes undergo epithelial-mesenchymal transition (EMT) and ferroptosis in response to hyperglycemic stimulation. This is considered an important early event in the development and progression of diabetic nephropathy (DN). Rhein is the main active anthraquinone derivative in several common traditional herbal medicines. This study aimed to investigate the protective effects of Rhein on podocyte ferroptosis and EMT. Methods: The mouse glomerular podocyte cell line MPC5 was stimulated with high glucose (HG), Rhein, and the ferroptosis inhibitor ferrostatin-1 (Fer-1). Mechanistic investigations employed plasmids to overexpress and knockdown Sirtuin-1 (SIRT1), solute carrier family 7 member 11 (SLC7A11),… More >

Siliang Liu^1,#, Hong Tang^2,#, Ying Xia¹, Zhengtao Yu¹, Ning Gao^1,*

BIOCELL, Vol.49, No.7, pp. 1245-1264, 2025, DOI:10.32604/biocell.2025.064396 - 25 July 2025

Abstract Objectives: NOD-like receptor family pyrin domain-containing (NLRP) 1-mediated pyroptosis plays a key role in the pathogenesis of cerebral ischemia-reperfusion injury (CIRI). C-Myc is reported to play a major role in CIRI. However, the mechanism remains unclear. This study aimed to investigate whether c-Myc affects CIRI by regulating Serine/Arginine-rich Splicing Factor 1 (SRSF1)/NLRP1-mediated pyroptosis. Methods: Oxygen-glucose deprivation/reperfusion (OGD/R) induced neuroblastoma cells for the establishment of an in vitro CIRI model. The levels of c-Myc and SRSF1, cell viability, the expression of pyroptosis-related factors, and the interaction between SRSF1 and NLRP1 were evaluated. Results: The expression of c-Myc and… More >

Myoung Cheol Shin¹, Tae-Kyeong Lee², Dae Won Kim³, Joon Ha Park⁴, Moo-Ho Won¹, Choong-Hyun Lee^5,*, Ji Hyeon Ahn^6,*

BIOCELL, Vol.49, No.6, pp. 1071-1083, 2025, DOI:10.32604/biocell.2025.065506 - 24 June 2025

Abstract Background: Astrocyte endfeet (AEF) serves as a key element of the blood-brain barrier and is important for the survival and maintenance of neuronal function. However, the immunohistochemical and ultrastructural changes of AEF in the CA1 and CA3 areas of the hippocampus over time following cerebral ischemia-reperfusion (IR) injury have not been well elucidated. Objectives: We investigated chronological changes in AEF in the gerbil hippocampal CA1 area from 3 h to 10 days following transient forebrain ischemia (TFI), and examined their association with neuronal death and tissue repair following IR injury. Changes in the CA3 area… More >

MINGZHI LUO^#,*, CHANGYU SUN^#, JIA GUO, XIANGRONG ZHANG, JING ZHANG, XUANYU SHI, LEI LIU, YAN PAN, JINGJING LI, LINHONG DENG^*

BIOCELL, Vol.49, No.5, pp. 833-855, 2025, DOI:10.32604/biocell.2025.063869 - 27 May 2025

Abstract Background: Mechanical ventilation (MV) provides life support for patients with severe respiratory distress but can simultaneously cause ventilator-induced lung injury (VILI). However, due to a poor understanding of its mechanism, there is still a lack of effective remedies for the often-deadly VILI. Recent studies indicate that the stretch associated with MV can enhance the secretion of extracellular vesicles (EVs) and induce endoplasmic reticulum (ER) stress in airway smooth muscle cells (ASMCs), both of which can contribute to VILI. But whether MV-associated stretch enhances the secretion of EVs via ER stress in ASMCs as an underlying… More > Graphic Abstract

Min Li^*

International Journal of Mental Health Promotion, Vol.27, No.1, pp. 89-95, 2025, DOI:10.32604/ijmhp.2024.057223 - 31 January 2025

Abstract Objectives: To explore the approaches for reducing non-suicidal self-injury (NSSI) behaviors in Chinese adolescents, the present study investigated the association between parent-child conflict and NSSI in adolescents, while also examining the mediating role of depression and the moderating role of rumination thinking. Methods: A cluster sampling method was employed to select 1227 Chinese adolescents aged 12 to 18 as participants, who completed measures including the Parent-Child conflict, Depression, Rumination Thinking, and Non-Suicidal Self-Injury questionnaires. The present study used SPSS 26.0 to conduct the Descriptive statistics, correlation analysis, and reliability tests, and PROCESS 3.3 to test… More >

JU-YEON LEE¹, DAEUN MOON², JINU KIM^2,3,*

BIOCELL, Vol.49, No.1, pp. 79-92, 2025, DOI:10.32604/biocell.2024.058340 - 24 January 2025

Abstract The epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein that plays a crucial role in signal transduction and cellular responses. This review explores the function of EGFR in kidney physiology and its implications for various kidney diseases. EGFR signaling is essential for kidney function and repair mechanisms, and its dysregulation significantly impacts both acute and chronic kidney conditions. The review discusses the normal distribution of EGFR in kidney tubular segments, the mechanism of its activation and inhibition, and the therapeutic potential of EGFR-targeting antagonists and ligands. Additionally, it explores the pathophysiological characteristics observed More >