Yiwen Li^1,#, Hongyan Si^1,#, Peng Wang¹, Hai Luo¹, Minggui Shen², Xiaoping Rao³, Zhanqian Song², Shibin Shang², Zongde Wang^1,*, Shengliang Liao^1,*

Journal of Renewable Materials, Vol.12, No.1, pp. 45-56, 2024, DOI:10.32604/jrm.2023.031089 - 23 January 2024

Abstract Turpentine is a renewable and resourceful forest product. The deep processing and utilization of turpentine, particularly its primary component β-pinene, has garnered widespread attention. This study aimed to synthesize 40 derivatives of β-pinene, including nopinone, 3-cyanopyridines of nopinone, myrtanyl acid, myrtanyl acylthioureas, and myrtanyl amides. We assessed the antiviral activities of these β-pinene derivatives against influenza virus A/Puerto Rico/8/34 (H1N1) using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. The β-pinene derivatives were used before and after cellular infection with the influenza virus to evaluate their preventive and therapeutic effects against the H1N1 virus. The results showed that only compound 10o More > Graphic Abstract

Sakda Noinang¹, Zulqurnain Sabir², Gilder Cieza Altamirano³, Muhammad Asif Zahoor Raja⁴, Manuel Jesús Sànchez-Chero⁵, María-Verónica Seminario-Morales⁵, Wajaree Weera^6,*, Thongchai Botmart⁶

CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 4851-4868, 2022, DOI:10.32604/cmc.2022.029437 - 28 July 2022

Abstract The current study relates to designing a swarming computational paradigm to solve the influenza disease system (IDS). The nonlinear system’s mathematical form depends upon four classes: susceptible individuals, infected people, recovered individuals and cross-immune people. The solutions of the IDS are provided by using the artificial neural networks (ANNs) together with the swarming computational paradigm-based particle swarm optimization (PSO) and interior-point scheme (IPA) that are the global and local search approaches. The ANNs-PSO-IPA has never been applied to solve the IDS. Instead a merit function in the sense of mean square error is constructed using More >

Jaeuk Moon, Seungwon Jung, Sungwoo Park, Eenjun Hwang^*

CMC-Computers, Materials & Continua, Vol.68, No.3, pp. 2945-2959, 2021, DOI:10.32604/cmc.2021.017435 - 06 May 2021

Abstract One popular strategy to reduce the enormous number of illnesses and deaths from a seasonal influenza pandemic is to obtain the influenza vaccine on time. Usually, vaccine production preparation must be done at least six months in advance, and accurate long-term influenza forecasting is essential for this. Although diverse machine learning models have been proposed for influenza forecasting, they focus on short-term forecasting, and their performance is too dependent on input variables. For a country’s long-term influenza forecasting, typical surveillance data are known to be more effective than diverse external data on the Internet. We… More >

WENBIAO CHEN, KEFAN BI, JINGJING JIANG, XUJUN ZHANG, HONGYAN DIAO^*

BIOCELL, Vol.45, No.4, pp. 885-899, 2021, DOI:10.32604/biocell.2021.012938 - 22 April 2021

Abstract The genome characteristics and structural functions of coding proteins correlate with the genetic diversity of the H1N1 virus, which aids in the understanding of its underlying pathogenic mechanism. In this study, analyses of the characteristic of the H1N1 virus infection-related genes, their biological functions, and infection-related reversal drugs were performed. Additionally, we used multi-dimensional bioinformatics analysis to identify the key genes and then used these to construct a diagnostic model for the H1N1 virus infection. There was a total of 169 differently expressed genes in the samples between 21 h before infection and 77 h… More >

Muhammad Adnan Khan^1,*, Wajhe Ul Husnain Abidi^1,2, Mohammed A. Al Ghamdi³, Sultan H. Almotiri³, Shazia Saqib¹, Tahir Alyas¹, Khalid Masood Khan¹, Nasir Mahmood⁴

CMC-Computers, Materials & Continua, Vol.66, No.1, pp. 331-340, 2021, DOI:10.32604/cmc.2020.012148 - 30 October 2020

Abstract Forecasting future outbreaks can help in minimizing their spread. Influenza is a disease primarily found in animals but transferred to humans through pigs. In 1918, influenza became a pandemic and spread rapidly all over the world becoming the cause behind killing one-third of the human population and killing one-fourth of the pig population. Afterwards, that influenza became a pandemic several times on a local and global levels. In 2009, influenza ‘A’ subtype H1N1 again took many human lives. The disease spread like in a pandemic quickly. This paper proposes a forecasting modeling system for the… More >