ZHEN WANG¹, JUN FU¹, SAISAI ZHU¹, HAODONG TANG², KUI SHI¹, JIHUA YANG³, MENG WANG³, MENGGE WU¹, DUNFENG QI^1,*

Oncology Research, Vol.32, No.12, pp. 1851-1866, 2024, DOI:10.32604/or.2024.055286 - 13 November 2024

Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) has a rich and complex tumor immune microenvironment (TIME). M2 macrophages are among the most extensively infiltrated immune cells in the TIME and are necessary for the growth and migration of cancers. However, the mechanisms and targets mediating M2 macrophage infiltration in pancreatic cancer remain elusive. Methods: The M2 macrophage infiltration score of patients was assessed using the xCell algorithm. Using weighted gene co-expression network analysis (WGCNA), module genes associated with M2 macrophages were identified, and a predictive model was designed. The variations in immunological cell patterns, cancer mutations, and… More > Graphic Abstract

Phi-Hung Nguyen^1,2,*

CMC-Computers, Materials & Continua, Vol.72, No.3, pp. 5059-5078, 2022, DOI:10.32604/cmc.2022.027630 - 21 April 2022

Abstract The main objective of this study is to comprehensively investigate individuals’ vaccination intention against COVID-19 during the second wave of COVID-19 spread in Vietnam using a novel hybrid approach. First, the Decision-Making Trial and Evaluation Laboratory based on Grey Theory (DEMATEL-G) was employed to explore the critical factors of vaccination intention among individuals. Second, Partial Least Squares-Structural Equation Modeling (PLS-SEM) was applied to test the hypotheses of individual behavioral intention to get the vaccine to prevent the outbreak of COVID-19. A panel of 661 valid respondents was collected from June 2021 to July 2021, and… More >

Fareeha Sameen¹, Abdul Momin Kazi², Majida Kazmi^1,*, Munir A Abbasi³, Saad Ahmed Qazi^1,4, Lampros K Stergioulas^3,5

CMC-Computers, Materials & Continua, Vol.70, No.1, pp. 375-395, 2022, DOI:10.32604/cmc.2022.019167 - 07 September 2021

Abstract Routine immunization (RI) of children is the most effective and timely public health intervention for decreasing child mortality rates around the globe. Pakistan being a low-and-middle-income-country (LMIC) has one of the highest child mortality rates in the world occurring mainly due to vaccine-preventable diseases (VPDs). For improving RI coverage, a critical need is to establish potential RI defaulters at an early stage, so that appropriate interventions can be targeted towards such population who are identified to be at risk of missing on their scheduled vaccine uptakes. In this paper, a machine learning (ML) based predictive… More >

Sadaf Qazi¹, Muhammad Usman¹, Azhar Mahmood¹, Aaqif Afzaal Abbasi², Muhammad Attique³, Yunyoung Nam^4,*

CMC-Computers, Materials & Continua, Vol.66, No.1, pp. 589-602, 2021, DOI:10.32604/cmc.2020.012507 - 30 October 2020

Abstract Immunization is a noteworthy and proven tool for eliminating lifethreating infectious diseases, child mortality and morbidity. Expanded Program on Immunization (EPI) is a nation-wide program in Pakistan to implement immunization activities, however the coverage is quite low despite the accessibility of free vaccination. This study proposes a defaulter prediction model for accurate identification of defaulters. Our proposed framework classifies defaulters at five different stages: defaulter, partially high, partially medium, partially low, and unvaccinated to reinforce targeted interventions by accurately predicting children at high risk of defaulting from the immunization schedule. Different machine learning algorithms are… More >

Jingping Song¹, Qingyu Meng¹, Chenke Luo², Nitin Naik³, Jian Xu^{1, *}

CMC-Computers, Materials & Continua, Vol.64, No.2, pp. 1051-1061, 2020, DOI:10.32604/cmc.2020.010592 - 10 June 2020

Abstract In recent years, as the popularity of anonymous currencies such as Bitcoin has made the tracking of ransomware attackers more difficult, the amount of ransomware attacks against personal computers and enterprise production servers is increasing rapidly. The ransomware has a wide range of influence and spreads all over the world. It is affecting many industries including internet, education, medical care, traditional industry, etc. This paper uses the idea of virus immunity to design an immunization solution for ransomware viruses to solve the problems of traditional ransomware defense methods (such as anti-virus software, firewalls, etc.), which… More >