Oncology Research Editorial Office

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.077269 - 30 December 2025

Abstract This article has no abstract. More >

Yechun Xin¹, Xinyuan Zhao¹, Dong Ding², Shuyu Chen², Chuanjie Wang², Tuo Wang^1,*

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.069748 - 27 December 2025

Abstract To enhance power flow regulation in scenarios involving large-scale renewable energy transmission via high-voltage direct current (HVDC) links and multi-infeed DC systems in load-center regions, this paper proposes a hybrid modular multilevel converter–capacitor-commutated line-commutated converter (MMC-CLCC) HVDC transmission system and its corresponding control strategy. First, the system topology is constructed, and a submodule configuration method for the MMC—combining full-bridge submodules (FBSMs) and half-bridge submodules (HBSMs)—is proposed to enable direct power flow reversal. Second, a hierarchical control strategy is introduced, including MMC voltage control, CLCC current control, and a coordination mechanism, along with the derivation of… More >

Sanghyuk Lee¹, Eunmi Lee^2,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-17, 2026, DOI:10.32604/cmc.2025.070504 - 09 December 2025

Abstract Hesitation analysis plays a crucial role in decision-making processes by capturing the intermediary position between supportive and opposing information. This study introduces a refined approach to addressing uncertainty in decision-making, employing existing measures used in decision problems. Building on information theory, the Kullback–Leibler (KL) divergence is extended to incorporate additional insights, specifically by applying temporal data, as illustrated by time series data from two datasets (e.g., affirmative and dissent information). Cumulative hesitation provides quantifiable insights into the decision-making process. Accordingly, a modified KL divergence, which incorporates historical trends, is proposed, enabling dynamic updates using conditional More >

Min Ma^1,2,3,#, Zhuxiu Wang^4,#, Yan Cao⁴, Juanying Yang⁴, Zeliang Zhuang⁵, Linqian Shi^4,*, Qian Gao^4,*

BIOCELL, Vol.49, No.12, pp. 2399-2413, 2025, DOI:10.32604/biocell.2025.071255 - 24 December 2025

Abstract Objectives: Keratin 6A (KRT6A) has been implicated in the progression of multiple malignancies; however, its expression pattern and biological role in cervical cancer (CC) have not been elucidated. This study aims to investigate KRT6A expression in CC tissues and evaluate its effects on cellular proliferation, migration, and invasion, thereby assessing its potential as a biomarker and therapeutic target. Methods: Differentially expressed genes were screened from the Gene Expression Omnibus (GEO) dataset (GSE9750) using the thresholds |log2FC| > 2 and false discovery rate (FDR) < 0.05. Immunohistochemistry was performed to evaluate KRT6A protein expression in tumor… More >

Oncology Research Editorial Offfce

Oncology Research, Vol.33, No.12, pp. 4159-4159, 2025, DOI:10.32604/or.2025.075992 - 27 November 2025

Abstract This article has no abstract. More >

Oncology Research Editorial Offfce

Oncology Research, Vol.33, No.12, pp. 4155-4155, 2025, DOI:10.32604/or.2025.075990 - 27 November 2025

Abstract This article has no abstract. More >

Rawabi S. Altuwayjiri, Ibtesam S. Almami^*

Oncology Research, Vol.33, No.12, pp. 3923-3943, 2025, DOI:10.32604/or.2025.070104 - 27 November 2025

Abstract Objective: Testicular germ cell tumors (TGCTs) represent the most common malignancy among young men aged 20–40 years. Transglutaminase 7 (TG7), encoded by TGM7, is a poorly characterized enzyme whose function in TGCT remains unknown. This study aimed to assess TG7 expression in clinical specimens and investigate its functional role in a testicular germ cell tumor cell line (NT2/D1). Methods: TG7 protein expression was evaluated in clinical testicular tissue samples via immunohistochemistry (IHC) and immunofluorescence (IF). Functional analysis was conducted in the NT2/D1 human testicular cancer cell line using Dicer-substrate small interfering RNAs (DsiRNAs) targeting TG7. Gene… More >

Fangyuan Li^1,2,#, Xiaoyuan Hu^1,#, Xiaoge Gao³, Ling Liu³, Tao Li¹, Dan He¹, Jiaxing Cheng¹, Xiaobiao Ma¹, Li Li^1,*, Chunlei Ge^1,*, Hong Yao^1,*

Oncology Research, Vol.33, No.12, pp. 4029-4048, 2025, DOI:10.32604/or.2025.067628 - 27 November 2025

Abstract Background: Liver cancer stem cells (LCSCs) are recognized as pivotal drivers of hepatocellular carcinoma (HCC) progression; however, the molecular mechanisms maintaining their stem-like phenotype remain largely unresolved. This work investigates the role of prefoldin subunit 6-like protein (PFDN6L) in shaping LCSC traits and promoting or restraining HCC progression. Methods: PFDN6L, a cytoskeleton-associated chaperone, was studied using multiple in vitro assays—cell growth evaluation, cell cycle profiling, and spheroid culture—alongside analyses of stemness-associated markers (SOX2, CD133, CD44). Tumorigenic capacity was assessed in xenograft mouse models, and signaling pathway interrogation was performed to define underlying mechanisms. Results: In patient samples, More >

S. Srinivasa senthil, K. Vijayakumar^*

Energy Engineering, Vol.122, No.12, pp. 5149-5173, 2025, DOI:10.32604/ee.2025.070889 - 27 November 2025

Abstract Heating, ventilation, and air conditioning (HVAC) systems contribute substantially to global energy consumption, while rejecting significant amounts of low-grade heat into the environment. This paper presents a non-intrusive spiral-coil heat exchanger designed to recover waste heat from the outdoor condenser of a split-type air conditioner. The system operates externally without altering the existing HVAC configuration, thereby rendering it suitable for retrofitting. Water was circulated as the working fluid at flow rates of 0.028–0.052 kg/s to assess thermal performance. Performance indicators, including the outlet water temperature, heat transfer rate, convective coefficient, and efficiency, were systematically evaluated.… More >

Shuxin Tan¹, Wei Yan², Lei Zhao¹, Xianglin Zhang^3,*, Ziqiang Man², Yu Lu², Teng Liu², Gaoyue Zhong², Weiqun Liu², Linjun Shi³

Energy Engineering, Vol.122, No.12, pp. 5175-5197, 2025, DOI:10.32604/ee.2025.068692 - 27 November 2025

Abstract The integration of large-scale renewable energy introduces frequency instability challenges due to inherent intermittency. While doubly-fed pumped storage units (DFPSUs) offer frequency regulation potential in pumping mode, conventional strategies fail to address hydraulic-mechanical coupling dynamics and operational constraints, limiting their effectiveness. This paper presents an innovative primary frequency control strategy for double-fed pumped storage units (DFPSUs) operating in pumping mode, integrating an adaptive parameter calculation method. This method is constrained by operational speed and power limits, addressing key performance factors. A dynamic model that incorporates the reversible pump-turbine characteristics is developed to translate frequency deviations… More >