Yuanyuan Yang¹, Xian Shi^1,2,*, Cheng Ji³, Yujie Yan³, Na An³, Teng Zhang⁴

Energy Engineering, Vol.121, No.12, pp. 3667-3688, 2024, DOI:10.32604/ee.2024.056266 - 22 November 2024

Abstract Based on a geology-engineering sweet spot evaluation, the high-quality reservoir zones and horizontal well landing points were determined. Subsequently, fracture propagation and production were simulated with a multilayer fracturing scenario. The optimal hydraulic fracturing strategy for the multilayer fracturing network was determined by introducing a vertical asymmetry factor. This strategy aimed to minimize stress shadowing effects in the vertical direction while maximizing the stimulated reservoir volume (SRV). The study found that the small vertical layer spacing of high-quality reservoirs and the presence of stress-masking layers (with a stress difference of approximately 3~8 MPa) indicate that… More > Graphic Abstract

Muhammad Abdullah Khan¹, Muhammad Usman², Yuhong Zhao^1,3,4,*

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 1905-1952, 2024, DOI:10.32604/cmc.2024.054691 - 18 November 2024

Abstract This comprehensive review examines the structural, mechanical, electronic, and thermodynamic properties of Mg-Li-Al alloys, focusing on their corrosion resistance and mechanical performance enhancement. Utilizing first-principles calculations based on Density Functional Theory (DFT) and the quasi-harmonic approximation (QHA), the combined properties of the Mg-Li-Al phase are explored, revealing superior incompressibility, shear resistance, and stiffness compared to individual elements. The review highlights the brittleness of the alloy, supported by B/G ratios, Cauchy pressures, and Poisson’s ratios. Electronic structure analysis shows metallic behavior with varied covalent bonding characteristics, while Mulliken population analysis emphasizes significant electron transfer within the… More >

WEITAO ZHENG¹, DONG JIANG², SONGEN CHEN¹, MEILING WU¹, BAOQI YAN², JIAHUI ZHAI², YUNQIANG SHI², BIN XIE¹, XINGWANG XIE², KANGHONG HU^1,*, WENXUE MA^3,*

Oncology Research, Vol.32, No.12, pp. 1837-1850, 2024, DOI:10.32604/or.2024.056565 - 13 November 2024

Abstract Objectives: The Kirsten rat sarcoma virus (KRAS) G12D oncogenic mutation poses a significant challenge in treating solid tumors due to the lack of specific and effective therapeutic interventions. This study aims to explore innovative approaches in T cell receptor (TCR) engineering and characterization to target the KRAS G12D_7-16 mutation, providing potential strategies for overcoming this therapeutic challenge. Methods: In this innovative study, we engineered and characterized two T cell receptors (TCRs), KDA11-01 and KDA11-02 with high affinity for the KRAS G12D_7-16 mutation. These TCRs were isolated from tumor-infiltrating lymphocytes (TILs) derived from tumor tissues of patients More >

Fan Yang^1,2,*, Honggang Mi^1,2, Jian Wu^1,2, Qi Yang^1,2

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.11, pp. 2637-2656, 2024, DOI:10.32604/fdmp.2024.048574 - 28 October 2024

Abstract The gas production of deep coalbed methane wells in Linxing-Shenfu block decreases rapidly, the water output is high, the supporting effect is poor, the effective supporting fracture size is limited, and the migration mechanism of proppant in deep coal reservoir is not clear at present. To investigate the migration behavior of proppants in complex fractures during the volume reconstruction of deep coal and rock reservoirs, an optimization test on the conductivity of low-density proppants and simulations of proppant migration in complex fractures of deep coal reservoirs were conducted. The study systematically analyzed the impact of… More >

Lei Zhang¹, Rongliang Shi^1,2,*, Junhui Li², Yannan Yu¹, Yu Zhang¹

Energy Engineering, Vol.121, No.11, pp. 3181-3197, 2024, DOI:10.32604/ee.2024.054485 - 21 October 2024

Abstract The grid-forming virtual synchronous generator (GFVSG) not only employs a first-order low-pass filter for virtual inertia control but also introduces grid-connected active power (GCAP) dynamic oscillation issues, akin to those observed in traditional synchronous generators. In response to this, an improved strategy for lead-lag filter based GFVSG (LLF-GFVSG) is presented in this article. Firstly, the grid-connected circuit structure and control principle of typical GFVSG are described, and a closed-loop small-signal model for GCAP in GFVSG is established. The causes of GCAP dynamic oscillation of GFVSG under the disturbances of active power command as well as More >

Xianghua Liu¹, Hai Song¹, Lu Zhao¹, Yan Zheng¹, Neng Yang², Dongling Qiu^2,*

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.10, pp. 2377-2392, 2024, DOI:10.32604/fdmp.2024.051418 - 23 September 2024

Abstract The segmented water control technology for bottom water reservoirs can effectively delay the entry of bottom water and adjust the production profile. To clarify the impact of different methods on horizontal well production with different reservoir conditions and to provide theoretical support for the scientific selection of methods for bottom water reservoirs, a numerical simulation method is presented in this study, which is able to deal with wellbore reservoir coupling under screen tube, perforation, and ICD (Inflow Control Device) completion. Assuming the geological characteristics of the bottom-water conglomerate reservoir in the Triassic Formation of the… More >

Zhaojie Sun¹, Linlin Xing^1,*, Longbo Zhang¹, Hongzhen Cai², Maozu Guo³

CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 4325-4340, 2024, DOI:10.32604/cmc.2024.053588 - 12 September 2024

Abstract Extracting valuable information from biomedical texts is one of the current research hotspots of concern to a wide range of scholars. The biomedical corpus contains numerous complex long sentences and overlapping relational triples, making most generalized domain joint modeling methods difficult to apply effectively in this field. For a complex semantic environment in biomedical texts, in this paper, we propose a novel perspective to perform joint entity and relation extraction; existing studies divide the relation triples into several steps or modules. However, the three elements in the relation triples are interdependent and inseparable, so we… More >

Sagar Kavaiya¹, Hiren Mewada^2,*, Sagarkumar Patel³, Dharmendra Chauhan³, Faris A. Almalki⁴, Hana Mohammed Mujlid⁴

CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 3685-3711, 2024, DOI:10.32604/cmc.2024.053587 - 12 September 2024

Abstract The mobility and connective capabilities of unmanned aerial vehicles (UAVs) are becoming more and more important in defense, commercial, and research domains. However, their open communication makes UAVs susceptible to undesirable passive attacks such as eavesdropping or jamming. Recently, the inefficiency of traditional cryptography-based techniques has led to the addition of Physical Layer Security (PLS). This study focuses on the advanced PLS method for passive eavesdropping in UAV-aided vehicular environments, proposing a solution to complement the conventional cryptography approach. Initially, we present a performance analysis of first-order secrecy metrics in 6G-enabled UAV systems, namely hybrid… More >

Qiang Liu¹, Rujun Wang¹, Yintao Zhang¹, Chong Sun¹, Meichun Yang¹, Yuliang Su^2,*, Wendong Wang², Ying Shi², Zheng Chen²

Energy Engineering, Vol.121, No.10, pp. 2797-2823, 2024, DOI:10.32604/ee.2024.052007 - 11 September 2024

Abstract Deep condensate gas reservoirs exhibit highly complex and variable phase behaviors, making it crucial to understand the relationship between fluid phase states and flow patterns. This study conducts a comprehensive analysis of the actual production process of the deep condensate gas well A1 in a certain oilfield in China. Combining phase behavior analysis and CMG software simulations, the study systematically investigates phase transitions, viscosity, and density changes in the gas and liquid phases under different pressure conditions, with a reservoir temperature of 165°C. The research covers three crucial depletion stages of the reservoir: single-phase flow,… More >

Mahzad Ahmed¹, Raja Mussadaq Yousaf², Ali Hassan^3,4,*, B. Shankar Goud⁵

Frontiers in Heat and Mass Transfer, Vol.22, No.4, pp. 1261-1276, 2024, DOI:10.32604/fhmt.2024.048091 - 30 August 2024

Abstract In the current work, inclined magnetic field, thermal radiation, and the Cattaneo-Christov heat flux are taken into account as we analyze the impact of chemical reaction on magneto-hydrodynamic Casson nanofluid flow on a stretching sheet. Modified Buongiorno’s nanofluid model has been used to model the flow governing equations. The stretching surface is embedded in a porous medium. By using similarity transformations, the nonlinear partial differential equations are transformed into a set of dimensionless ordinary differential equations. The numerical solution of transformed dimensionless equations is achieved by applying the shooting procedure together with Rung-Kutta 4th-order method… More >