Lijun Mu, Xiaojia Xue, Jie Bai^*, Xiaoyan Li, Xueliang Han

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1365-1379, 2024, DOI:10.32604/fdmp.2024.049013

Abstract Following large-scale volume fracturing in shale oil reservoirs, well shut-in measures are generally employed. Laboratory tests and field trials have underscored the efficacy of fracturing fluid imbibition during the shut-in phase in augmenting shale oil productivity. Unlike conventional reservoirs, shale oil reservoirs exhibit characteristics such as low porosity, low permeability, and rich content of organic matter and clay minerals. Notably, the osmotic pressure effects occurring between high-salinity formation water and low-salinity fracturing fluids are significant. The current understanding of the mobilization patterns of crude oil in micro-pores during the imbibition process remains nebulous, and the… More >

Huiyan Zhao¹, Xuezhong Chen¹, Zhijian Hu^2,*, Man Chen¹, Bo Xiong³, Jianying Yang¹

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.6, pp. 1313-1330, 2024, DOI:10.32604/fdmp.2024.048840

Abstract Using the typical characteristics of multi-layered marine and continental transitional gas reservoirs as a basis, a model is developed to predict the related well production rate. This model relies on the fractal theory of tortuous capillary bundles and can take into account multiple gas flow mechanisms at the micrometer and nanometer scales, as well as the flow characteristics in different types of thin layers (tight sandstone gas, shale gas, and coalbed gas). Moreover, a source-sink function concept and a pressure drop superposition principle are utilized to introduce a coupled flow model in the reservoir. A… More > Graphic Abstract

Jianchao Shi^1,2, Yanan Zhang³, Wantao Liu^1,2, Yuliang Su^3,*, Jian Shi^1,2

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 1147-1163, 2024, DOI:10.32604/fdmp.2023.044500

Abstract Class III tight oil reservoirs have low porosity and permeability, which are often responsible for low production rates and limited recovery. Extensive repeated fracturing is a well-known technique to fix some of these issues. With such methods, existing fractures are refractured, and/or new fractures are created to facilitate communication with natural fractures. This study explored how different refracturing methods affect horizontal well fracture networks, with a special focus on morphology and related fluid flow changes. In particular, the study relied on the unconventional fracture model (UFM). The evolution of fracture morphology and flow field after More >

Fang Li^1,*, Juan Wu¹, Haiyong Yi², Lihong Wu², Lingyun Du¹, Yuan Zeng¹

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 1015-1030, 2024, DOI:10.32604/fdmp.2023.043256

Abstract Methods for horizontal well spacing calculation in tight gas reservoirs are still adversely affected by the complexity of related control factors, such as strong reservoir heterogeneity and seepage mechanisms. In this study, the stress sensitivity and threshold pressure gradient of various types of reservoirs are quantitatively evaluated through reservoir seepage experiments. On the basis of these experiments, a numerical simulation model (based on the special seepage mechanism) and an inverse dynamic reserve algorithm (with different equivalent drainage areas) were developed. The well spacing ranges of Classes I, II, and III wells in the Q gas More > Graphic Abstract

Lian Liu^1,2, Liang Li^1,2, Kebo Jiao^1,2,*, Junwei Fang^1,2, Yun Luo^1,2

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 975-987, 2024, DOI:10.32604/fdmp.2023.030109

Abstract Ultra-deep reservoirs play an important role at present in fossil energy exploitation. Due to the related high temperature, high pressure, and high formation fracture pressure, however, methods for oil well stimulation do not produce satisfactory results when conventional fracturing fluids with a low pumping rate are used. In response to the above problem, a fracturing fluid with a density of 1.2~1.4 g/cm was developed by using Potassium formatted, hydroxypropyl guanidine gum and zirconium crosslinking agents. The fracturing fluid was tested and its ability to maintain a viscosity of 100 mPa.s over more than 60 min More >

Min Zhao^*, Zhiying Su^†, Shiyang Zhang^‡, Liangjin Zhuang^§, Yudi Xie^*, Xiaodong Li^*

Oncology Research, Vol.24, No.5, pp. 353-360, 2016, DOI:10.3727/096504016X14685034103275

Abstract Ovarian cancer (OC) is one of the most common gynecological malignancies. MicroRNAs (miRs) play a crucial role in the development and progression of OC, but the underlying mechanism remains largely unclear. Our study investigated the regulatory role of miR-148a in OC cell proliferation and invasion. We found that miR- 148a was significantly downregulated in OC tissues compared to their matched adjacent nontumor tissues. In addition, its expression was also reduced in OC cell lines (SKOV3, ES-2, OVCAR, and A2780) compared to normal ovarian epithelial cells. Overexpression of miR-148a caused a significant decrease in OC cell… More >

Annie Im, Ali Amjad, Mounzer Agha, Anastasios Raptis, Jing-Zhou Hou, Rafic Farah, Seah Lim, Alison Sehgal, Kathleen A. Dorritie, Robert L. Redner, Brian McLaughlin, Yongli Shuai, Shrina Duggal, Michael Boyiadzis

Oncology Research, Vol.24, No.2, pp. 73-80, 2016, DOI:10.3727/096504016X14586627440156

Abstract Relapsed acute myeloid leukemia (AML) represents a major therapeutic challenge. Achieving complete remission (CR) with salvage chemotherapy is the first goal of therapy for relapsed AML. However, there is no standard salvage chemotherapy. The current study evaluated outcomes and prognostic factors for achievement of CR in 91 AML patients in first relapse who were treated with the mitoxantrone–etoposide combination regimen. The overall response rate (CR and CRi) was 25%. Factors that were associated with a lower rate of CR included older age, shorter duration of first CR, low hemoglobin, and low platelet count. The median… More >

Ling Liu, Nianfeng Li, Qi Zhang, Jixiang Zhou, Ling Lin, Xinxin He

Oncology Research, Vol.25, No.9, pp. 1607-1616, 2017, DOI:10.3727/096504017X14938093512742

Abstract Transforming growth factor-b (TGF-β) and ERK signaling have been implicated in various human cancers including hepatocellular carcinoma, but the underlying mechanism remains largely unclear. In this study, we aimed to explore the role of ERK1/2 in the regulation of TGF-β’s promoting and suppressive activities in HCC cells. Our data showed that treatment with TGF-β1 enhanced invasion and epithelial–mesenchymal transition (EMT) in HCC HepG2 cells, accompanied with increased MMP9 production and activation of Smad2/3 and ERK1/2, but inhibited tumor cell proliferation. These effects were eliminated by treatment with SB431542, a TGF-β inhibitor. Afterward, treatment with the… More >

Hui Li^*, Zhigang Xiang^*, Yan Liu^*, Bin Xu^*, Jianzhou Tang^†

Oncology Research, Vol.25, No.8, pp. 1269-1282, 2017, DOI:10.3727/096504017X14850151453092

Abstract MicroRNAs (miRs), a class of small noncoding RNAs, are key gene regulators through inducing translational repression or degradation of their target genes. However, the regulatory mechanism of miR-133b underlying hepatocellular carcinoma (HCC) growth and metastasis remains largely unclear. Here we found that miR-133b was significantly downregulated in HCC tissues and cell lines. Moreover, low miR-133b levels were significantly associated with the malignant progression of HCC. LASP1, upregulated in HCC tissues and cell lines, was then identified as a novel target of miR-133b in HCC HepG2 and Hep3B cells. Moreover, the increased expression of LASP1 was… More >

HaiYan Yang^*†, ZhiGang Peng^†, ZhenZhen Da^*, Xin Li^‡, YeXiao Cheng^*, BinBin Tan^§, Xin Xiang^¶, HaiPing Zheng^†, Yan Li^*, LanHua Chen^*, Ning Mo^†, XueXin Yan^†, Xiaolin Li^*, XiaoHua Hu^†

Oncology Research, Vol.25, No.8, pp. 1231-1243, 2017, DOI:10.3727/096504017X14850134190255

Abstract MicroRNAs (miRs) have been demonstrated to be involved in the development and progression of osteosarcoma (OS), but the molecular mechanism still remains to be fully investigated. The present study investigated the function of miR-148a in OS, as well as its underlying mechanism. Our data showed that miR-148a was significantly downregulated in OS tissues compared to their matched adjacent normal tissues, and also in OS cell lines compared to normal human osteoblast cells. Low expression of miR-148a was significantly associated with tumor progression and a poor prognosis for OS patients. Rho-associated coiled-coil kinase 1 (ROCK1) was… More >