Keiko Yanagihara^1,*, Masato Yoshida², Kensaku Awaji², Tamami Yamakawa¹, Sena Kato¹, Miki Tamura¹, Koji Nagata³

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.073891 - 30 December 2025

Abstract Background: Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have transformed the management of hormone receptor–positive/HER2–negative (HR+/HER2–) advanced breast cancer, yet evidence for elderly or poor-performance patients remains limited. This study examined real-world outcomes of palbociclib plus endocrine therapy in Asian patients, with additional subgroup analyses by age and performance status. Methods: We retrospectively analyzed 46 consecutive Asian patients with recurrent or de novo HR+/HER2− breast cancer treated with first-line palbociclib plus ET between April 2021 and March 2025. The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall response rate (ORR), disease control rate (DCR), and safety.… More >

Xia Yan¹, Wei Wang¹, Kai Shen^2,*, Yanqing Feng¹, Junyi Sun¹, Xiaogang Li¹, Wentao Zhu¹, Binbin Shi¹, Guanglong Sheng^2,3

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.070360 - 27 December 2025

Abstract In the development of coalbed methane (CBM) reservoirs using multistage fractured horizontal wells, there often exist areas that are either repeatedly stimulated or completely unstimulated between fracturing stages, leading to suboptimal reservoir performance. Currently, there is no well-established method for accurately evaluating the effectiveness of such stimulation. This study introduces, for the first time, the concept of the Fracture Network Bridging Coefficient (FNBC) as a novel metric to assess stimulation performance. By quantitatively coupling the proportions of unstimulated and overstimulated volumes, the FNBC effectively characterizes the connectivity and efficiency of the fracture network. A background… More >

Hong Zhao, Hongbin Chen^*, Zhihui Guo, Ling Zhan, Shichao Li

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-25, 2026, DOI:10.32604/cmc.2025.072776 - 09 December 2025

Abstract UAV-mounted intelligent reflecting surface (IRS) helps address the line-of-sight (LoS) blockage between sensor nodes (SNs) and the fusion center (FC) in Internet of Things (IoT). This paper considers an IoT assisted by multiple UAVs-mounted IRS (U-IRS), where the data from ground SNs are transmitted to the FC. In practice, energy efficiency (EE) and mission completion time are crucial metrics for evaluating system performance and operational costs. Recognizing their importance during data collection, we formulate a multi-objective optimization problem to maximize EE and minimize total mission completion time simultaneously. To characterize this tradeoff while considering optimization… More >

Yonggang Tong^1,*, Kai Yang¹, Pengfei Li¹, Yongle Hu¹, Xiubing Liang^2,*, Jian Liu³, Yejun Li⁴, Jingzhong Fang¹

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-15, 2026, DOI:10.32604/cmc.2025.071890 - 10 November 2025

Abstract (NbZrHfTi)C high-entropy ceramics, as an emerging class of ultra-high-temperature materials, have garnered significant interest due to their unique multi-principal-element crystal structure and exceptional high-temperature properties. This study systematically investigates the mechanical properties of (NbZrHfTi)C high-entropy ceramics by employing first-principles density functional theory, combined with the Debye-Grüneisen model, to explore the variations in their thermophysical properties with temperature (0–2000 K) and pressure (0–30 GPa). Thermodynamically, the calculated mixing enthalpy and Gibbs free energy confirm the feasibility of forming a stable single-phase solid solution in (NbZrHfTi)C. The calculated results of the elastic stiffness constant indicate that the… More >

S. Saleem^a, U. Parveen^a, H. AL-Ghamdi^b,*, M. Yaseen^a, I. Sajjad^a, Nasarullah^a

Chalcogenide Letters, Vol.22, No.3, pp. 223-237, 2025, DOI:10.15251/CL.2025.223.223

Abstract Present research reveals the doping effect on physical properties of Sr_1-xFe_xS by employing ab-initio calculations. The negative formation energy and optimization outcomes exhibit the stability of the Sr_1-xFe_xS alloys with ferromagnetic phase. Spin dependent band structure (BS) and density of states (DOS) interpret that Sr_1-xFe_xS revealed half metallic ferromagnetic (HMF) nature at 6.25% and 12.5% of Fe doping while metallic character is revealed at 25% concentration of dopant. Spin-up state of Sr_0.9375Fe_0.0625S and Sr_0.8750Fe_0.1250S depicts semiconductive behavior with bandgap value of 2.01/2.33 eV, correspondingly, while metallic in spin-down channel. The magnetism in the system is mainly originated because… More >

Q. N. Gao^a, H. L. Zhang^a, Z. H. Dong^a, Y. J. Liu^b, N. N. Zhou^a, P. P. Zhang^a, J. Wang^c,*

Chalcogenide Letters, Vol.22, No.3, pp. 205-221, 2025, DOI:10.15251/CL.2025.223.205

Abstract The structural, mechanical, electronic, and thermodynamic properties of CuC_xSnC_1-xTe (x = 0, 0.03125, 0.0625, 0.125, and 0.25) are investigated through first-principles calculations. The studied structures are all cubic and own negative enthalpy of formation. The elastic constants and mechanical properties (B, G, E and ν) are predicted. The bandgap of SnTe evaluated by HSE06 is 0.25 eV, closing to the experimental data 0.19 eV. All studied Cu-doped compounds behave metallic. In addition, the thermodynamic properties (G, H, S, C_P, and CC_V) of the materials, together with the bulk modulus and thermal expansion coefficient versus temperature have been More >

I. Sajjad^a, U. Parveen¹, H. Al-Ghamdi^b,*, M. Yaseen^a, S. Saleem^a, Nasarullah^a

Chalcogenide Letters, Vol.22, No.9, pp. 829-845, 2025, DOI:10.15251/CL.2025.229.829

Abstract Herein, we employed modified Becke-Johson (mBJ) potential based first principles method to investigate the structural, optoelectronic, and magnetic properties of pure SrS and Ni doped Sr_1-xNi_xS alloys at varying doping concentrations. Formation enthalpy analysis predicts thermodynamical stability of resultant alloys. Geometry optimization was performed in order to optimize the super cells to obtain ground state energy state. After confirming their stability, we investigated their magnetic, electronic, and optical attributes. Pure SrS exhibits an indirect band gap of 3.53 eV (which is in good agreement with experiments), while nickel doping in SrS results in lowering the bandgap… More >

Yang Dou¹, Hao Qin¹, Yuzhi Zhang^1,2, Ning Wang¹, Haiqing Liu^3,4, Wanli Yang^1,2,4,*

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.11, pp. 2673-2700, 2025, DOI:10.32604/fdmp.2025.069719 - 01 December 2025

Abstract In recent years, tuned liquid dampers (TLDs) have attracted significant research interest; however, overall progress has been limited due to insufficient understanding of the mechanisms governing sloshing-induced loads. In particular, it remains unclear whether the water in aqueducts—common water-diversion structures in many countries—can serve as an effective TLD. This study investigates the generation mechanisms of sloshing loads during the first-order transverse resonance of water in a U-shaped aqueduct using a two-dimensional (2D) numerical model. The results reveal that, at the equilibrium position, the free surface difference between the left and right walls, the horizontal force… More >

Bo Wang¹, Fuyang Wu², Zifeng Chen², Libin Dai¹, Yifan Dong¹, Xiaotao Gao³, Zongfa Li^2,*

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.11, pp. 2701-2719, 2025, DOI:10.32604/fdmp.2025.067298 - 01 December 2025

Abstract Tight gas reservoirs are often characterized by pronounced heterogeneity and poor continuity, resulting in wide variability in production enhancement and net present value (NPV) for different geological parameter combinations (see e.g., the Ordos Basin). The conditions governing geological adaptability remain insufficiently defined. To address these challenges, this study integrates large-volume hydraulic fracturing, numerical production simulation, and economic evaluation to elucidate the mechanisms by which large-scale fracturing enhances fracture parameters in tight gas formations. The analysis reveals that, for identical proppant and fluid volumes, increasing the fracturing injection rate leads to longer and taller fractures. Over… More >

Hai Li¹, Ziqiang Xia^2,3,*, Majia Zheng⁴, Weiyang Xie^2,3, Jianlin Li¹, Ruiqi Gao^2,3, Gaoxiang Wang^2,3, Jiangrong Feng^2,3

Energy Engineering, Vol.122, No.12, pp. 5039-5054, 2025, DOI:10.32604/ee.2025.069036 - 27 November 2025

Abstract To explore and evaluate the longitudinal utilization degree of marine shale gas horizontal wells in southern Sichuan Basin (hereinafter referred to as “southern Sichuan”), focusing on the shale of Wufeng formation-Longyi1 sub-member in the deep Z block. By using the data from core experiments, well logging, and fracture height detection, a systematic analysis from the perspectives of reservoir distribution, longitudinal utilization height of hydraulic fractures, and longitudinal utilization degree of horizontal wells was conducted. The research results show that: (1) The overall reservoir conditions of the Wufeng formation-Longyi1 sub-member in the study area are relatively… More > Graphic Abstract