Oncology Research Editorial Office

Oncology Research, Vol.32, No.8, pp. 1373-1373, 2024, DOI:10.32604/or.2024.055031

Abstract This article has no abstract. More >

Rudraneel Dutta^*, Shreya Mohanty

Journal on Artificial Intelligence, Vol.6, pp. 177-192, 2024, DOI:10.32604/jai.2024.050706

Abstract Traditionally, exam preparation involves manually analyzing past question papers to identify and prioritize key topics. This research proposes a data-driven solution to automate this process using techniques like Document Layout Segmentation, Optical Character Recognition (OCR), and Latent Dirichlet Allocation (LDA) for topic modelling. This study aims to develop a system that utilizes machine learning and topic modelling to identify and rank key topics from historical exam papers, aiding students in efficient exam preparation. The research addresses the difficulty in exam preparation due to the manual and labour-intensive process of analyzing past exam papers to identify… More >

Tengfei Li¹, Wenhui Zhang¹, Ke Mi¹, Qingming Lin¹, Shuangwei Zhao^2,*, Jiayi Song²

Energy Engineering, Vol.121, No.7, pp. 1991-2007, 2024, DOI:10.32604/ee.2024.049460

Abstract Aiming at the problem of energy storage unit failure in the spring operating mechanism of low voltage circuit breakers (LVCBs). A fault diagnosis algorithm based on an improved Sparrow Search Algorithm (ISSA) optimized Backpropagation Neural Network (BPNN) is proposed to improve the operational safety of LVCB. Taking the 1.5kV/4000A/75kA LVCB as an example. According to the current operating characteristics of the energy storage motor, fault characteristics are extracted based on Empirical Wavelet Transform (EWT). Traditional BPNN has problems such as difficulty adjusting network weights and thresholds, being sensitive to initial weights, and quickly falling into More >

Xiang Kan¹, Yan Li², Tian Li^1,*, Jiye Zhang¹

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 1075-1091, 2024, DOI:10.32604/fdmp.2023.044050

Abstract A pantograph serves as a vital device for the collection of electricity in trains. However, its aerodynamic resistance can limit the train’s running speed. As installing fairings around the pantograph is known to effectively reduce the resistance, in this study, different fairing lengths are considered and the related aerodynamic performances of pantograph are assessed. In particular, this is accomplished through numerical simulations based on the k-ω Shear Stress Transport (SST) two-equation turbulence model. The results indicate that the fairing diminishes the direct impact of high-speed airflow on the pantograph, thereby reducing its aerodynamic resistance. However, it More >

Hong Pang¹, Ao Lu¹, Ming Xiong¹, Chen Chen¹, Xian Cao¹, Xiong Xu^2,3,*, Jing Wang¹

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 1063-1074, 2024, DOI:10.32604/fdmp.2023.044000

Abstract Conventional repairing methods for asphalt pavement have some inconveniences, such as insufficient strength, and are typically time-consuming. To address these issues, this study proposes a new technological method to design and prepare a high-performance assembled asphalt concrete block for fast repair of the potholes. A series of composite modified asphalt binders with 10% crumb rubber (CR) and different dosages (0%, 1%, 3%, 5%) of polyurethane (PU) are examined to determine the optimized binder. Subsequently, the corresponding asphalt mixtures are prepared for further comparison and assessment of engineering properties, such as moisture-induced damage, high-temperature deformation, and More >

Vesna Vetma^*†‡, Jan Rožanc^§, Emilie M. Charles^*†, Christian T. Hellwig^*†‡¶, Leonidas G. Alexopoulos^§#, Markus Rehm^*†‡#

Oncology Research, Vol.25, No.9, pp. 1489-1494, 2017, DOI:10.3727/096504017X14897145996933

Abstract Antagonists of inhibitors of apoptosis proteins (IAPs), alone or in combination with genotoxic therapeutics, have been shown to efficiently induce cell death in various solid tumors. The IAP antagonist birinapant is currently being tested in phase II clinical trials. We herein aimed to investigate the antitumor efficacy of dacarbazine in vitro, both as a single agent and in combination with birinapant, in melanoma cell lines. Covering clinically relevant drug concentration ranges, we conducted a total of 5,400 measurements in a panel of 12 human melanoma cell lines representing different stages of disease progression. Surprisingly, functionally More >

Cheng-Jen Ma^*†‡, Ching-Wen Huang^*‡§, Yung-Sung Yeh^*†¶, Hsiang-Lin Tsai^*§#**, Huang-Ming Hu^††‡‡, I-Chen Wu^††‡‡, Tian-Lu Cheng^§§¶¶, Jaw-Yuan Wang^{*†‡§**¶¶}

Oncology Research, Vol.25, No.5, pp. 673-679, 2017, DOI:10.3727/97818823455816X14786040691928

Abstract We analyzed the results of previously treated patients with metastatic colorectal cancer (mCRC) who received regorafenib plus FOLFIRI with the irinotecan dose escalation on the basis of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotyping. Thirteen patients with previously treated mCRC were subjected to UGT1A1 genotyping between October 2013 and June 2015 and were administered regorafenib plus FOLFIRI with irinotecan dose escalation. Patients with UGT1A1*1/*1 and *1/*28 genotypes were administered 180 mg/m² of irinotecan, whereas those with the UGT1A1*28/*28 genotype were administered 120 mg/m2 of irinotecan. For all patients, the irinotecan dose was increased by 30 mg/m2 every… More >

Ghobad Shafiei Sabet^1,*, Ali Sari¹, Ahmad Fakhari^2,*, Nasrin Afsarimanesh³, Dominic Organ⁴, Seyed Mehran Hoseini¹

Frontiers in Heat and Mass Transfer, Vol.22, No.2, pp. 491-509, 2024, DOI:10.32604/fhmt.2024.048290

Abstract This study conducts both numerical and empirical assessments of thermal transfer and fluid flow characteristics in a Solar Air Collector (SAC) using a Delta Wing Vortex Generator (DWVG), and the effects of different height ratios (R = 0.6, 0.8, 1, 1.2 and 1.4) in delta wing vortex generators, which were not considered in the earlier studies, are investigated. Energy and exergy analyses are performed to gain maximum efficiency. The Reynolds number based on the outlet velocity and hydraulic diameter falls between 4400 and 22000, corresponding to the volume flow rate of 5.21–26.07 m/h. It is More >

Jipeng Xie^1,2, Guolai Yang^1,*, Liqun Wang¹, Lei Li¹

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 793-819, 2024, DOI:10.32604/cmes.2024.048174

Abstract To enhance the comprehensive performance of artillery internal ballistics—encompassing power, accuracy, and service life—this study proposed a multi-stage multidisciplinary design optimization (MS-MDO) method. First, the comprehensive artillery internal ballistic dynamics (AIBD) model, based on propellant combustion, rotation band engraving, projectile axial motion, and rifling wear models, was established and validated. This model was systematically decomposed into subsystems from a system engineering perspective. The study then detailed the MS-MDO methodology, which included Stage I (MDO stage) employing an improved collaborative optimization method for consistent design variables, and Stage II (Performance Optimization) focusing on the independent optimization More >

Dengke Xu¹, Linlin Shen¹, Fangzhong Xu^2,*

International Journal of Mental Health Promotion, Vol.26, No.3, pp. 229-238, 2024, DOI:10.32604/ijmhp.2024.046023

Abstract Based on China Family Panel Studies (CFPS) 2018 data, the multiple linear regression model is used to analyze the effects of Internet use on women’s depression, and to test the robustness of the regression results. At the same time, the effects of Internet use on mental health of women with different residence, age, marital status and physical health status are analyzed. Then, we can obtain that Internet use has a significant promoting effect on women’s mental health, while the degree of Internet use has a significant inhibitory effect on women’s mental health. In addition, the… More >