Gaowu Hu*, Ye Xu*, Wenquan Chen*, Jiandong Wang†, Chunying Zhao†1, Ming Wang*1
Oncology Research, Vol.24, No.6, pp. 455-461, 2016, DOI:10.3727/096504016X14685034103635
Abstract Breast cancer is a highly prevalent disease affecting women. The association of IQ motif containing GTPaseactivating protein 3 (IQGAP3) and breast cancer is poorly defined. Here we reported that IQGAP3 is a key
regulator of cell proliferation and metastasis during breast cancer progression. The expression of IQGAP3
was significantly increased in breast tissues compared to nontumor tissues at both protein and mRNA levels.
Furthermore, IQGAP3 had a high expression level in ZR-75-30 and BT474 compared to other breast cancer
cell lines. Depletion of IQGAP3 through RNA interference in ZR-75-30 and BT474 significantly inhibited cell proliferation. More >
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