Qingzhu Ma*, Yan Wang†, Hualing Zhang*, Fengqiang Wang†
Oncology Research, Vol.26, No.8, pp. 1167-1174, 2018, DOI:10.3727/096504017X15051741798389
Abstract Colorectal cancer (CRC) is one of the most common oncological conditions worldwide, to date. MicroRNA-
1290 (miR-1290) has been demonstrated to regulate its progression. We studied the role of miR-1290 in CRC
progression. The gene was upregulated in CRC tissues and cells. Its overexpression promoted CRC cell proliferation analyzed by MTT assay, colony formation assay, and soft agar growth assay. In addition, miR-1290
knockdown inhibited CRC cell proliferation. We also found that miR-1290 overexpression reduced the p27
level and increased cyclin D1 at both the mRNA and protein levels, whereas miR-1290 knockdown increased
p27 and More >
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