Rong Wang, Yunfeng Wu, Weihua Huang, Weijun Chen
Oncology Research, Vol.26, No.1, pp. 145-155, 2018, DOI:10.3727/096504017X14902261600566
Abstract In this report, we aimed to explore the role and regulatory mechanism of microRNA-940 (miR-940) in bladder
cancer development. The expressions of miR-940 in bladder cancer tissues and cells were measured. miR-940
mimics, miR-940 inhibitor small interference RNA against INPP4A (si-INPP4A), and GSK3b (si-GSK3b)
and their corresponding controls were then transfected into cells. We investigated the effects of miR-940,
INPP4A, or GSK3b on cell proliferation, migration, invasion, and apoptosis. Additionally, target prediction
and luciferase reporter assays were performed to investigate the targets of miR-940. The regulatory relationship
between miR-940 and the Wnt/β-catenin pathway was also… More >