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  • Open Access

    ARTICLE

    An active RUNX1-ID1/ID3 axis governs differentiation and chemoresistance of cancer stem cell population in epithelial ovarian cancer cells

    AJIT C. DHADVE1,2, PRITHA RAY1,2

    BIOCELL, Vol.46, No.1, pp. 75-86, 2022, DOI:10.32604/biocell.2022.016346

    Abstract Progression, relapse, and therapy resistance are the most challenging features of cancer therapy that have been postulated to be driven by Cancer Stem Cell (CSC) population. This enigmatic subpopulation of cancer cells has therefore emerged as promising therapeutic candidate. We earlier reported enrichment of CSC-like side population (SP) with increasing resistance towards Cisplatin and Paclitaxel either alone or in combination in epithelial ovarian cancer (EOC) cells. This SP population is a small proportion of the total population of cancer cells characterised with high expression of drug transporters, a unique feature of stem cells and thereby can be isolated through their… More >

  • Open Access

    ARTICLE

    Intelligent Decision Support System for COVID-19 Empowered with Deep Learning

    Shahan Yamin Siddiqui1,2, Sagheer Abbas1, Muhammad Adnan Khan3,*, Iftikhar Naseer4, Tehreem Masood4, Khalid Masood Khan3, Mohammed A. Al Ghamdi5, Sultan H. Almotiri5

    CMC-Computers, Materials & Continua, Vol.66, No.2, pp. 1719-1732, 2021, DOI:10.32604/cmc.2020.012585

    Abstract The prompt spread of Coronavirus (COVID-19) subsequently adorns a big threat to the people around the globe. The evolving and the perpetually diagnosis of coronavirus has become a critical challenge for the healthcare sector. Drastically increase of COVID-19 has rendered the necessity to detect the people who are more likely to get infected. Lately, the testing kits for COVID-19 are not available to deal it with required proficiency, along with-it countries have been widely hit by the COVID-19 disruption. To keep in view the need of hour asks for an automatic diagnosis system for early detection of COVID-19. It would… More >

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