Yimin Liu^1,#, Bin Liu^2,3,4,#, Huabin Gao¹, Jinlong Wang⁵, Jingya Duan¹, Xiaolan Huang¹, Yuexi Liu¹, Ying Huang¹, Wenjing Liao¹, Ruonan Li^1,*, Hua Linghu^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069007 - 30 December 2025

Abstract Objectives: High-grade serous ovarian cancer (HGSOC), the most common subtype of epithelial ovarian cancer (EOC), exhibits a mesenchymal phenotype characterized by fibrotic stroma and poor prognosis. Human epididymis protein 4 (HE4), a key diagnostic biomarker for ovarian cancer, is involved in fibrotic processes in several non-malignant diseases. Given the clinical significance of stromal fibrosis in HGSOC and the potential link between HE4 and fibrosis, this study aimed to investigate the role of HE4 in the formation of stromal fibrosis in HGSOC. Methods: A total of 126 patients with gynecological conditions were included and divided into… More > Graphic Abstract

Bindi Saurabh Thakkar¹, Pradeep Kumar Karsh^2,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-22, 2026, DOI:10.32604/cmc.2025.072839 - 09 December 2025

Abstract This study investigates the uncertain dynamic characterization of hybrid composite plates by employing advanced machine-assisted finite element methodologies. Hybrid composites, widely used in aerospace, automotive, and structural applications, often face variability in material properties, geometric configurations, and manufacturing processes, leading to uncertainty in their dynamic response. To address this, three surrogate-based machine learning approaches like radial basis function (RBF), multivariate adaptive regression splines (MARS), and polynomial neural networks (PNN) are integrated with a finite element framework to efficiently capture the stochastic behavior of these plates. The research focuses on predicting the first three natural frequencies… More >

Yan Li^1,2,*, Yibin Wu^1,2, Bo Zhang^1,2

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.12, pp. 2905-2925, 2025, DOI:10.32604/fdmp.2025.072979 - 31 December 2025

Abstract Traditional Computational Fluid Dynamics (CFD) simulations are computationally expensive when applied to complex fluid–structure interaction problems and often struggle to capture the essential flow features governing vortex-induced vibrations (VIV) of floating structures. To overcome these limitations, this study develops a hybrid framework that integrates high-fidelity CFD modeling with deep learning techniques to enhance the accuracy and efficiency of VIV response prediction. First, an unstructured finite-volume fluid–structure coupling model is established to generate high-resolution flow field data and extract multi-component time-series feature tensors. These tensors serve as inputs to a Squeeze-and-Excitation Convolutional Neural Network (SE-CNN), which… More >

Jordan L. Mendelson^1,*, Jordan Kassab¹, Phillip Westbrook¹, Katie Yang², Anthony Corcoran¹

Canadian Journal of Urology, Vol.32, No.6, pp. 673-676, 2025, DOI:10.32604/cju.2025.063770 - 30 December 2025

Abstract Stereotactic body radiotherapy (SBRT) for prostate cancer is a generally well-tolerated treatment but can rarely lead to complications such as fistula formation. We report a 69-year-old male on maintenance ibrutinib for chronic lymphocytic leukemia who developed a fistula between his bladder and vas deferens in the setting of ascending scrotal infection. Despite his prior history of SBRT, the fistula was successfully treated with minimally invasive measures. A combination of abscess debridement, urinary diversion, and broad-spectrum antibiotics helped to achieve fistula resolution. The unique presentation described herein highlights the importance of early aggressive intervention for source More >

Huiping Qiu¹, Shaofang Huang^2,*, Xin Xiong¹, Li Zhang¹

BIOCELL, Vol.49, No.12, pp. 2415-2432, 2025, DOI:10.32604/biocell.2025.070402 - 24 December 2025

Abstract Background: Pulmonary fibrosis is an irreversible lung disorder that currently has a limited number of effective therapeutic strategies. Taraxasterol (TAR), a bioactive triterpenoid isolated from plants used in traditional Chinese medicine (TCM), possesses anti-inflammatory and antioxidant activities. However, its precise role in pulmonary fibrosis remains incompletely defined. This study aimed to elucidate whether TAR alleviates pulmonary fibrosis by modulating Protein Phosphatase 2 Scaffold Subunit Abeta (PPP2R1B) expression. Methods: A bleomycin-induced murine model of pulmonary fibrosis and a transforming growth factor-β1 (TGF-β1) stimulated mouse lung fibroblast cell line (MLg) were established. To evaluate the effects of… More >

Yunjun Lee¹, Sanggyu Cheon², Woo Chul Chung^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 3381-3403, 2025, DOI:10.32604/cmes.2025.073729 - 23 December 2025

Abstract The application of carbon capture systems on ships is technically constrained by limited onboard space and the weight of the conventional absorption tower. The rotating packed bed (RPB) has emerged as a promising alternative due to its small footprint and high mass transfer performance. However, despite its advantages, the structural and vibration stability of RPBs at high rotational speed remains insufficiently studied, and no international design standards currently exist for RPBs. To address this gap, this study performed a comprehensive finite element analysis (FEA) using ANSYS to investigate the structural and dynamic characteristics of an… More >

Michał Guminiak¹, Marcin Kamiński^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 3133-3163, 2025, DOI:10.32604/cmes.2025.071887 - 23 December 2025

Abstract The analysis of the dynamics of surface girders is of great importance in the design of engineering structures such as steel welded bridge plane girders or concrete plate-column structures. This work is an extension of the classical deterministic problem of free vibrations of thin (Kirchhoff) plates. The main aim of this work is the study of stochastic eigenvibrations of thin (Kirchhoff) elastic plates resting on internal continuous and column supports by the Boundary Element Method (BEM). This work is a continuation of previous research related to the random approach in plate analysis using the BEM.… More >

Sewwandi Tennakoon¹, Eric Danso¹, Zhenjie Zhao^2,*

Journal on Artificial Intelligence, Vol.7, pp. 517-547, 2025, DOI:10.32604/jai.2025.072628 - 01 December 2025

Abstract Generative Artificial Intelligence (GenAI) systems have achieved remarkable capabilities across text, code, and image generation; however, their outputs remain prone to errors, hallucinations, and biases. Users often overtrust these outputs due to limited transparency, which can lead to misuse and decision errors. This study addresses the challenge of calibrating trust in GenAI through a human centered testing framework enhanced with adaptive explainability. We introduce a methodology that adjusts explanations dynamically according to user expertise, model output confidence, and contextual risk factors, providing guidance that is informative but not overwhelming. The framework was evaluated using outputs… More >

Chaonan Xin^*, Keqing Xu

Journal of Cyber Security, Vol.7, pp. 483-503, 2025, DOI:10.32604/jcs.2025.071627 - 28 November 2025

Abstract Intrusion Detection Systems (IDS) have achieved high accuracy on benchmark datasets, yet models often fail to generalize across different network environments. In this paper, we propose Transformer-IDS, a transformer-based network intrusion detection model designed for cross-dataset generalization. The model incorporates a classification token, multi-head self-attention, and embedding layers to learn versatile features, and it introduces a calibration module and an AUC-oriented optimization objective to improve reliability and ranking performance. We evaluate Transformer-IDS on three prominent datasets (NSL-KDD, UNSW-NB15, CIC-IDS2017) in both within-dataset and cross-dataset scenarios. Results demonstrate that while conventional deep IDS models (e.g., CNN-LSTM More >

Meile Li¹, Yinuo Jiang^2,*

Journal on Artificial Intelligence, Vol.7, pp. 509-516, 2025, DOI:10.32604/jai.2025.073792 - 28 November 2025

Abstract This paper conducts topic mining and analysis of research literature in the domestic smart library field based on the BERTopic model, aiming to reveal its topic development context and evolution trends. Journal literature in the smart library field collected by CNKI (China National Knowledge Infrastructure) from 2015 to 2024 was analyzed using the BERTopic model and dynamic topic modeling for topic mining and evolution trend analysis. The study found that the domestic smart library field involves multiple core topics, identifying a diversified topic structure centered around “data”, “user”, “5g”, etc. The research results provide data More >