Ming Liu, Dan Wang, Ning Li
Oncology Research, Vol.23, No.5, pp. 257-266, 2015, DOI:10.3727/096504016X14562725373752
Abstract Osteosarcoma (OS) is the most common malignant primary bone tumor disease. HIF-1α was predicted to be
the target gene of microRNA-20b (miR-20b). The present study was designed to illustrate the effect of miR-
20b in regulating osteosarcoma via targeting HIF-1α. In this study, we found that the expression of HIF-1α
was significantly increased, while miR-20b obviously decreased in OS patients and OS cell lines compared
with healthy controls. Moreover, the luciferase report confirmed the targeting reaction between miR-20b and
HIF-1α. Additionally, the overexpression of miR-20b suppressed the invasion and growth of both MG63 and
U2OS More >
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