Dmytro A. Kiriziy¹, Oksana V. Dubrovna¹, Oksana G. Sokolovska-Sergiienko¹, Alina S. Holoboroda¹, Victor V. Rohach^1,2, Oleg O. Stasik^1,*

Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2026.075371 - 30 January 2026

Abstract Water scarcity severely constrains the genetic potential of wheat yield worldwide. Proline is among the most versatile stress-related metabolites in plants, and targeting genes involved in proline synthesis and degradation represents a promising strategy for developing drought-tolerant wheat genotypes. This study evaluates the performance of the photosynthetic apparatus in transgenic wheat line with RNAi-mediated suppression of proline dehydrogenase (ProDH) and in the original (wild-type) genotype, under both drought and recovery conditions. Drought was induced at the flowering stage by lowering soil moisture to 30% field capacity for 7 days, compared with 70% field capacity in… More >

JOSé A. BOGA^1,2, ANA COTO-MONTES^2,3,*, RUSSEL J. REITER⁴

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.068245 - 23 January 2026

Abstract Aerobic glycolysis, also known as the Warburg effect, and the accumulation of lactate that it causes, are increasingly recognized outside the field of oncology as triggers of chronic non-neoplastic disorders. This review integrates preclinical and clinical evidence to evaluate the ability of melatonin to reverse Warburg-effect-like metabolic reprogramming. Literature on neurodegeneration, age-related sarcopenia, type 2 diabetes, chronic kidney disease, heart failure and pulmonary arterial hypertension (PAH) has been reviewed and synthesised. In all of these conditions, hypoxia-inducible factor 1α (HIF-1α) and pyruvate dehydrogenase kinase 4 (PDK4) inhibit the pyruvate dehydrogenase complex. This diverts pyruvate away… More >

Xinyang Li^1,2,3,#, Luyuan Ma^1,2,3,#, Chuan Shen^1,2,3, Ruolan Gu^1,2,3, Shilong Dong^1,2,3, Mingjie Liu^1,2,3, Ying Xiao^1,2,3, Wenpeng Liu^1,2,3, Yuexia Liu^1,2,3, Caiyan Zhao^1,2,3,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.073179 - 19 January 2026

Abstract Background: Hepatocellular carcinoma (HCC) is an aggressive and lethal malignancy. Metabolic reprogramming dynamically remodels the tumor microenvironment (TME) and drives HCC progression. This study investigated the mechanism through which metabolic reprogramming remodels the TME in HCC. Methods: HCC patient transcriptome data were subjected to bioinformatics analysis to identify differentially expressed genes and immune infiltration status. Immunohistochemical analysis was performed to determine the correlation between succinate dehydrogenase complex subunit A (SDHA) expression and M2 macrophage infiltration. SDHA-knockdown or SDHA-overexpressing HCC cells were used for in vitro experiments, including co-culturing, flow cytometry, and enzyme-linked immunosorbent assay. Western blotting… More >

Wei-Ting Hsueh^1,#, Kwang-Yu Chang^1,2,3,#, Chin-Chuan Tsai^4,5, Kuan-Tso Chen^5,6, Kuen-Jang Tsai⁷, Zi-Xuan Hong⁸, Chan-Chuan Liu², Jui-Mei Chu², Li-Ying Qiu², Yu-Yan Lan⁸, Chia-Hung Chien^8,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071258 - 19 January 2026

Abstract Objectives: Glioblastoma (GBM) is a prevalent malignant brain tumor prone to drug resistance. We previously found a strong correlation between SH3 domain GRB2-like endophilin B1 (SH3GLB1) and superoxide dismutase 2 (SOD2), which converts O₂ to hydrogen peroxide (H₂O₂). Prior studies show that H₂O₂ redox signaling is vital for physiological processes and can drive tumor progression. Therefore, we aim to define how H₂O₂ signaling regulates SH3GLB1 and AKT (protein kinase B) pathways in GBM and to assess whether modulating H₂O₂ reverses temozolomide (TMZ) resistance. Methods: We used cultured cells and pharmacological inhibitors and activators to confirm the significance of… More > Graphic Abstract

Xue Zhang¹, Jie Chen^2,*, Zhihui Zhang³, Dewei Zhang³, Yuejiao Ming³, Xinde Zhang³

Energy Engineering, Vol.123, No.1, 2026, DOI:10.32604/ee.2025.069487 - 27 December 2025

Abstract The integration of wind power and natural gas for hydrogen production forms a Green and Blue Hydrogen Integrated Energy System (GBH-IES), which is a promising cogeneration approach characterized by multi-energy complementarity, flexible dispatch, and efficient utilization. This system can meet the demands for electricity, heat, and hydrogen while demonstrating significant performance in energy supply, energy conversion, economy, and environment (4E). To evaluate the GBH-IES system effectively, a comprehensive performance evaluation index system was constructed from the 4E dimensions. The fuzzy DEMATEL method was used to quantify the causal relationships between indicators, establishing a scientific input-output… More > Graphic Abstract

Mengjie Wang¹, Jingfa Li^2,*, Bo Yu², Nianrong Wang³, Xiaofeng Wang³, Tao Hu⁴

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.12, pp. 3055-3072, 2025, DOI:10.32604/fdmp.2025.071675 - 31 December 2025

Abstract The adaptation of existing natural gas pipelines for hydrogen transportation has attracted increasing attention in recent years. Yet, whether hydrogen and natural gas stratify under static conditions remains a subject of debate, and experimental evidence is still limited. This study presents an experimental investigation of the concentration distribution of hydrogen–natural gas mixtures under static conditions. Hydrogen concentration was measured using a KTL-2000M-H hydrogen analyzer, with a measurement range of 0–30% (by volume), an accuracy of 1% full scale (FS), and a resolution of 0.01%. Experiments were conducted in a 300 cm riser, filled with uniformly… More >

C. M. Fu^a, M. Z. Ge^b, X. Q. Zhang^c, W. Yan^c,*

Chalcogenide Letters, Vol.22, No.8, pp. 665-677, 2025, DOI:10.15251/CL.2025.228.665

Abstract Constructing heterojunctions represents a crucial strategy for enhancing semiconductor photocatalysts. In this study, the C-MoO₂/Cd_0.9Zn_0.1S S-scheme heterojunction composite was successfully fabricated through a self-assembly approach. XPS analysis confirmed the spontaneous transfer of intrinsic electrons from Cd_0.9Zn_0.1S to C-MoO₂ in the dark, establishing an internal electric field at the C-MoO2/Cd_0.9Zn_0.1S interface. Under visible light irradiation, the C-MoO₂/Cd_0.9Zn_0.1S composite exhibited significantly enhanced hydrogen evolution activity, achieving a 6.3-fold improvement compared to pristine Cd_0.9Zn_0.1S. PL, TRPL, and electrochemical measurements collectively demonstrated that the incorporation of C-MoO₂ effectively suppressed the recombination of photogenerated electrons in Cd_0.9Zn_0.1S. The outstanding photocatalytic performance and improved charge More >

Wang Gu¹, Yuanyuan Song², Zhihu Zhang³, Minggang Zheng^1,*

Energy Engineering, Vol.122, No.12, pp. 4837-4856, 2025, DOI:10.32604/ee.2025.069529 - 27 November 2025

Abstract Driven by the global “dual-carbon” goals, hydrogen fuel cell electric vehicles (FCEVs) are being rapidly promoted as a zero-emission transportation solution. However, their large-scale application is constrained by issues such as inefficient operation, poor information flow between vehicles and stations, and potential safety hazards, which are caused by insufficient intelligence of hydrogen refueling stations. This study aims to address these problems by deeply integrating Cellular Vehicle-to-Everything (C-V2X) technology with hydrogen refueling stations, thereby building a safe, efficient, and low-carbon hydrogen energy application ecosystem to promote the global transition to zero-carbon transportation. Firstly, through literature review… More >

Baiyue Song¹, Chenxi Zhang², Wei Zhang^2,*, Leiyu Wan²

Energy Engineering, Vol.122, No.12, pp. 4919-4945, 2025, DOI:10.32604/ee.2025.068971 - 27 November 2025

Abstract Hydrogen energy is a crucial support for China’s low-carbon energy transition. With the large-scale integration of renewable energy, the combination of hydrogen and integrated energy systems has become one of the most promising directions of development. This paper proposes an optimized scheduling model for a hydrogen-coupled electro-heat-gas integrated energy system (HCEHG-IES) using generative adversarial imitation learning (GAIL). The model aims to enhance renewable-energy absorption, reduce carbon emissions, and improve grid-regulation flexibility. First, the optimal scheduling problem of HCEHG-IES under uncertainty is modeled as a Markov decision process (MDP). To overcome the limitations of conventional deep… More >

Jack Kiing Teck Wei¹, Mohanad Taher Mohamed Sayed Roshdy¹, Bryan Ho Liang Hui¹, Jalal Tavalaei¹, Hadi Nabipour Afrouzi^2,*

Energy Engineering, Vol.122, No.11, pp. 4755-4775, 2025, DOI:10.32604/ee.2025.069980 - 27 October 2025

Abstract In this article, a hybrid energy storage system powered by renewable energy sources is suggested, which is connected to a grid-tied electric vehicle charging bay (EVCB) in Sarawak and is examined for its techno-economic effects. With a focus on three renewable energy sources, namely hydrokinetic power, solar power, and hydrogen fuel cells, the study seeks to minimize reliance on the electrical grid while meeting the growing demand from the growing electric vehicle (EV) infrastructure. A hybrid renewable energy storage system that combines solar power, hydrogen fuel cells, hydrokinetic power, and the grid was simulated and… More >