Jing Cai^1,#, Haoyun Zhu^1,#, Weiling Guo¹, Ting Huang¹, Pangzhou Chen^1,2, Wen Zhou¹, Ziyun Guan^1,3,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069902 - 30 December 2025

Abstract Background: Therapeutic responses of breast cancer vary among patients and lead to drug resistance and recurrence due to the heterogeneity. Current preclinical models, however, are inadequate for predicting individual patient responses towards different drugs. This study aimed to investigate the patient-derived breast cancer culture models for drug sensitivity evaluations. Methods: Tumor and adjacent tissues from female breast cancer patients were collected during surgery. Patient-derived breast cancer cells were cultured using the conditional reprogramming technique to establish 2D models. The obtained patient-derived conditional reprogramming breast cancer (CRBC) cells were subsequently embedded in alginate-gelatin methacryloyl hydrogel microspheres… More >

Shaojian Zou^1,#, Lipeng Zhang^2,#, Xiang Chen^3,#, Zhuomin Wang², Xinhui Zhu², Dandong Luo⁴, Shengxun Mao^2,*, Zhen Zong^2,*

Oncology Research, Vol.33, No.12, pp. 3753-3788, 2025, DOI:10.32604/or.2025.067586 - 27 November 2025

Abstract Traditional cancer therapies have limitations like poor efficacy on advanced tumors, healthy tissue damage, side effects, and drug resistance, creating an urgent need for new strategies. Hydrogels have good biocompatibility and controlled release, while extracellular vesicles (EVs) enable targeting and bioactive transport. This review systematically summarizes hydrogels and EVs, focusing on the construction of hydrogel-EV delivery system, key influencing factors, drug delivery mechanisms, and tumor therapy apps, clarifying their synergies. The system overcomes single-carrier flaws, construction methods/key factors affect performance, preclinical studies have confirmed efficacy in multiple therapies, but large-scale production and in vivo stability challenges More >

Kaidi Luo¹, Weihuang Cai², Huazhen Liu¹, Yi Zhang², Kailei Pan², Xiaoyi Wang¹, Yuanyuan Liu^1,2*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.2, pp. 1-1, 2025, DOI:10.32604/icces.2025.011866

Abstract As the global prevalence of diabetes continues to rise, chronic diabetic wounds have become an important cause of amputation and death due to their protracted nature. In order to break through the limitations of traditional dressings, this study innovatively constructed a GelMA/HAMA-CS/PCL composite hydrogel-scaffold system containing chitosan based on biomaterials engineering and 3D printing technology. The system provides biomimetic ECM microenvironment through: photocrosslinked hydrogel layer (GelMA/HAMA-CS); Electrostatic spinning PCL film achieves mechanical strengthening and barrier protection. The chitosan component imparts long-term antibacterial activity, and the multi-materials cooperate to promote wound healing. In vitro antibacterial and… More >

Caixia Chen¹, Pengyu Liu¹, Changhua Wang¹, Yanyan Xie¹, Wei Wang^1,*, Xiaomin Kang^2,*

Journal of Polymer Materials, Vol.42, No.3, pp. 621-660, 2025, DOI:10.32604/jpm.2025.068852 - 30 September 2025

Abstract Due to their high water content, stimulus responsiveness, and biocompatibility, hydrogels, which are functional materials with a three-dimensional network structure, are widely applied in fields such as biomedicine, environmental monitoring, and flexible electronics. This paper provides a systematic review of hydrogel characterization methods and their applications, focusing on primary evaluation techniques for physical properties (e.g., mechanical strength, swelling behavior, and pore structure), chemical properties (e.g., composition, crosslink density, and degradation behavior), biocompatibility, and functional properties (e.g., drug release, environmental stimulus response, and conductivity). It analyzes the challenges currently faced by characterization methods, such as a More >

Yinglai Tang, Jiale Xie, Yujie Chen, Xingxu Liu, Xiaomin Kang^*

Journal of Polymer Materials, Vol.42, No.3, pp. 587-619, 2025, DOI:10.32604/jpm.2025.067647 - 30 September 2025

Abstract With the rapid development of flexible and wearable electronic devices, the demand for flexible power sources with high energy density and long service life is imminent. Zinc-air batteries have long been regarded as an important development direction in the future due to their high safety, environmental efficiency, abundant reserves and low cost. However, problems such as zinc dendrite growth, corrosion, by-product generation, hydrogen evolution and leakage, and evaporation of electrolyte affect the commercialization of zinc-air batteries. In addition, currently widely used aqueous electrolytes lead to larger batteries, which is not conducive to the development of… More >

Nanpu Cao¹, Huan Luo¹, Song Yue¹, Yong Chen¹, Mao Xu¹, Pu Cao¹, Tao Xin¹, Hongying Luo¹, Fa Zhang^2,*

Journal of Polymer Materials, Vol.42, No.3, pp. 661-675, 2025, DOI:10.32604/jpm.2025.067313 - 30 September 2025

Abstract This review systematically summarizes recent advancements in the design of antibacterial hydrogels and the surface-related factors influencing microbial adhesion to polymeric materials. Hydrogels, characterized by their three-dimensional porous architecture and ultra-high water content, serve as ideal platforms for incorporating antibacterial agents (e.g., metal ions, natural polymers) through physical/chemical interactions, enabling sustained release and enhanced antibacterial efficacy. For traditional polymers, surface properties (e.g., roughness, charge, superhydrophobicity, free energy, nanoforce gradients) play critical roles in microbial adhesion. Modifying the surface properties of polymers through surface treatment can regulate antibacterial performance. In particular, by referencing the micro/nanostructures found More >

Imandeena Sofileeya^1,2, Surajudeen Sikiru^1,2,*, Nur Hidayah Shahemi¹, Niraj Kumar³, Mohd Muzamir Mahat^1,*

Journal of Polymer Materials, Vol.42, No.3, pp. 713-728, 2025, DOI:10.32604/jpm.2025.065378 - 30 September 2025

Abstract Spinal cord injury presents a significant challenge in regenerative medicine due to the complex and delicate nature of neural tissue repair. This study aims to design a conductive hydrogel embedded with magnetic MgFe₂O₄ nanoparticles to establish a bioelectrically active and spatially stable microenvironment that promotes spinal cord regeneration through computational analysis (BIOVIA Materials Studio). Hydrogels, known for their biocompatibility and extracellular matrix-mimicking properties, support essential cellular behaviors such as adhesion, proliferation, and migration. The integration of MgFe₂O₄ nanoparticles imparts both electrical conductivity and magnetic responsiveness, enabling controlled transmission of electrical signals that are crucial for guiding… More >

Tarek Dayyoub^1,2,*, Mikhail Zadorozhnyy^1,2, Dmitriy G. Ladokhin¹, Emil Askerov¹, Ksenia V. Filippova¹, Lidiia D. Iudina¹, Elizaveta Iushina¹, Dmitry V. Telyshev^1,3, Aleksey Maksimkin¹

Journal of Renewable Materials, Vol.13, No.7, pp. 1267-1292, 2025, DOI:10.32604/jrm.2025.02024-0022 - 22 July 2025

Abstract The development of actuators based on ionic polymers as soft robotics, artificial muscles, and sensors is currently considered one of the most urgent topics. They are lightweight materials, in addition to their high efficiency, and they can be controlled by a low power source. Nevertheless, the most popular ionic polymers are derived from fossil-based resources. Hence, it is now deemed crucial to produce these actuators using sustainable materials. In this review, the use of ionic polymeric materials as actuators is reviewed through the emphasis on their role in the domain of renewable materials. The review… More > Graphic Abstract

Kunlin Wu, Jingcheng Xiao, Junwei Li, Yifan Wang^*

Journal of Polymer Materials, Vol.42, No.2, pp. 277-305, 2025, DOI:10.32604/jpm.2025.065269 - 14 July 2025

Abstract The integration of 3D-printed hydrogels in soft robotics enables the creation of flexible, adaptable, and biocompatible systems. Hydrogels, with their high-water content and responsiveness to stimuli, are suitable for actuators, sensors, and robotic systems that require safe interaction and precise manipulation. Unlike traditional techniques, 3D printing offers enhanced capabilities in tailoring structural complexity, resolution, and integrated functionality, enabling the direct fabrication of hydrogel systems with programmed mechanical and functional properties. In this perspective, we explore the evolving role of 3D-printed hydrogels in soft robotics, covering their material composition, fabrication techniques, and diverse applications. We highlight More >

Hanyi Zou^1,2,#, Xinye Xu^1,3,#, Mutian Yao¹, Baoyang Lu^1,*

Journal of Polymer Materials, Vol.42, No.2, pp. 339-358, 2025, DOI:10.32604/jpm.2024.057955 - 14 July 2025

Abstract The global scarcity of clean water is an escalating issue due to climate change, population growth, and pollution. Traditional water purification technologies, while effective, often require significant energy input and complex infrastructure, limiting their accessibility. This review explores the use of conjugated polymer hydrogels as a promising solution for solar water purification. Conjugated polymer hydrogels offer unique advantages, including high photothermal conversion efficiency, effective heat management, and rapid water transport, which are crucial for efficient solar-driven water evaporation. By leveraging the properties of these hydrogels, it is possible to significantly reduce the energy required for More >