Minglei Zhang*, Dapeng Wang†, Tongtong Zhu*, Ruofeng Yin*
Oncology Research, Vol.25, No.1, pp. 75-81, 2017, DOI:10.3727/096504016X14719078133401
Abstract MicroRNAs (miRNAs) are small conserved RNAs regulating specific target genes in posttranscriptional
levels. They have been involved in multiple processes of tumor progression, including cell proliferation.
miR-214-5p (also miR-214*) is a newly identified miRNA, and its functions are largely unknown. In this
study, we explore the role of miR-214-5p in the proliferation and invasion of human osteosarcoma (OS)
cells. The results showed that miR-214-5p was sharply reduced in OS tissues and cell lines, compared
with normal tissues and cell lines. In addition, the miR-214-5p mimic greatly increased the miR-214-5p
level and significantly decreased the proliferation More >
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