Xiangrui Meng^*1, Xiaoqi Chen^†1, Peng Lu^‡, Wang Ma^*, Dongli Yue^*, Lijie Song^*, Qingxia Fan^*

Oncology Research, Vol.25, No.2, pp. 215-223, 2017, DOI:10.3727/096504016X14732772150541

Abstract Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant cancers with high mortality around the world. However, the regulatory mechanism of ESCC carcinogenesis is not completely known. Here we demonstrate the novel role of miR-202 in regulating ESCC cell apoptosis. The analysis of data obtained from the GEO database showed that the expression of miR-202 is aberrantly decreased in tumor tissue from ESCC patients and cultured ESCC cell lines. After transfection with miR-202 mimic or inhibitor, the apoptotic capacity of ESCC cells was significantly increased by miR-202 overexpression but reduced by miR-202… More >

LEI YU^1,2, ZHEN FAN³, HONGQIANG WANG², WENXIAN LI⁴, TAO JING², QIANG LI², SHENQIAN LI², PEITAO WANG², XUJUN XUAN^1,*

BIOCELL, Vol.45, No.2, pp. 323-329, 2021, DOI:10.32604/biocell.2021.09034

Abstract This worked aimed to test the hypothesis that L-alanyl-L-glutamine (Ala-Gln) improves the varicocele-induced testicular injury, which causes male infertility. For this purpose, fifty adult male Wistar rats received the varicocele (VC) surgery at the left renal vein. Biomarkers were determined 2, 4, and 8 weeks after VC (n = 10/each detection). Four weeks after VC, rats received Ala-Gln (1.125 g/kg) treatment with and or saline for 1 week (n = 10/each group). Rats in the sham group were also detected for biomarkers at 2, 4, and 8 weeks (n = 10/each detection). VC caused testicular… More >

LUCIANA MAZZEI^1,2, MARÍA BELÉN RUIZ-ROSO³, NATALIA DE LAS HERAS³, SANDRA BALLESTEROS³, CAROLINA TORRESPALAZZOLO⁴, LEÓN FERDER⁵, ALEJANDRA BEATRIZ CAMARGO⁴, WALTER MANUCHA^1,2,*

BIOCELL, Vol.44, No.4, pp. 671-681, 2020, DOI:10.32604/biocell.2020.014175

Abstract The ancestral cultures have described many therapeutic properties of garlic; therefore, it is of central interest to elucidate the molecular basis explaining this millenary empirical knowledge. Indeed, it has been demonstrated a neuroprotective effect of allicin–a phytochemical present in garlic- linked to oxidative-inflammatory modulation. Allicin improved neuronal injury by heat shock protein 70 (Hsp70) and inducible nitric oxide synthase (iNOS) regulation. Also, allicin exerts renal protection involving a possible angiotensin type 1 receptor (AT1) interaction. In connection, AT1 overexpression has been recognized as a central deleterious factor in many brain diseases. However, there are no… More >

LUCIANA MAZZEI¹, ISABEL MERCEDES GARCÍA¹, VALERIA CACCIAMANI¹, MARÍA EUGENIA BENARDÓN¹ AND WALTER MANUCHA^{1, 2, 3}

BIOCELL, Vol.34, No.3, pp. 121-132, 2010, DOI:10.32604/biocell.2010.34.121

Abstract Wilms tumor gene 1 (wt-1), a key regulator of mesenchymal-epithelial transformation, is downregulated during congenital obstructive nephropathy, leading to apoptosis. There is a functional interaction between WT-1 and inducible nitric oxide synthase (iNOS). In this regard, we reported that after neonatal unilateral ureteral obstruction, rosuvastatin prevents apoptosis through an increase in nitric oxide bioavailability, which in turn is linked to higher Hsp70 expression. Hence, the goal of this study was to determine whether a nitric oxide/Hsp70 interaction is involved in changes in WT-1 mRNA expression after ureteral obstruction. Neonatal rats submitted to experimental ureteral obstruction were… More >

CLAUDIA FERNANDA NOME¹ , SERGIO FERNANDO NOME² , FABIANA GUZMÁN¹ , LUIS CONCI¹, IRMA GRACIELA LAGUNA^1,2

BIOCELL, Vol.31, No.1, pp. 23-31, 2007, DOI:10.32604/biocell.2007.31.023

Abstract Among diseases reported worldwidely for sweet potato (Ipomoea batatas (L) Lam) crop, one of the most frequent is the Sweet potato virus disease (SPVD), caused by sweet potato chlorotic stunt virus (SPCSV) and sweet potato feathery mottle virus (SPFMV) co-infection. In Argentina, there exists the sweet potato chlorotic dwarf (SPCD), a sweet potato disease caused by triple co-infection with SPCSV, SPFMV and sweet potato mild speckling virus(SPMSV). Both diseases cause a synergism between the potyviruses(SPFMV and SPMSV) and the crinivirus (SPCSV). Up to date, studies carried out on the interaction among these three viruses have… More >

M. V. Kurian¹, J. M. Mullins¹, L. R. Hamilton¹, P. M. Mehl², J. K. Keevan²

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 217-218, 2006, DOI:10.32604/mcb.2006.003.217

Abstract This article has no abstract. More >

Zongqiang GAO¹, Xiong GUO², Junchang CHEN¹, Chen DUAN²

BIOCELL, Vol.43, No.2, pp. 99-102, 2019, DOI:10.32604/biocell.2019.06520

Abstract This study aimed to investigate the effect of hyaluronic acid (HA) on the expression of heat shock protein 70 (HSP70) in chondrocytes isolated from patients with osteoarthritis (OA) and Kashin-Beck disease (KBD). The chondrocytes were collected from OA and KBD patients, and chondrocytes isolated from patients of accident injuries were used as the control. The chondrocytes were treated with HA at different doses. HSP70 expression in chondrocytes at both mRNA and protein levels was tested by PCR and Western blot analysis. Compared with control, both mRNA and protein levels of HSP70 were higher in chondrocytes More >