Lei Yang*, Fei Xie†, Shuangqing Li‡
Oncology Research, Vol.25, No.7, pp. 1089-1095, 2017, DOI:10.3727/096504016X14784668796788
Abstract Homeobox B7 (HOXB7), a member of the HOX gene family, plays a role in tumorigenesis. However, until
now the expression status and role of HOXB7 in osteosarcoma remain unclear. Therefore, the present study
aimed to investigate the functional role and mechanism of HOXB7 in osteosarcoma. Our results demonstrated
that HOXB7 was overexpressed in osteosarcoma cell lines. Downregulation of HOXB7 significantly inhibited
osteosarcoma cell proliferation in vitro, as well as attenuated xenograft tumor growth in vivo. Downregulation
of HOXB7 also inhibited the migration and invasion of osteosarcoma cells. Furthermore, downregulation
of HOXB7 significantly suppressed the protein More >
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