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    ARTICLE

    Mesenchymal stem cells are more effective than captopril in reverting cisplatin-induced nephropathy

    Entsar A. SAAD1, Reda S. EL-DEMERDASH2, Eman M. ABD EI-FATTAH1

    BIOCELL, Vol.43, No.2, pp. 73-80, 2019, DOI:10.32604/biocell.2019.07020

    Abstract Cisplatin is a powerful anticancer drug but its nephrotoxic effects limit its clinical use. We aimed to evaluate the effect of mesenchymal stem cells (MSCs) injection or of captopril to counteract the cisplatin-induction of nephropathy. MSCs isolation, preparation and tracking, transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) expressions, kidney function tests, oxidative stress state, and histological examinations were done. Cisplatininduced nephropathy was indicated biochemically and confirmed histopathologically. MSCs treatment showed normal kidney architecture, and significantly decreased oxidative stress and TGF-β while increased IL-10 and improved kidney function tests. Rats treated with cisplatin + captopril More >

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