Qianren Xiao*1, Lu Huang†1, Zhongzu Zhang‡1, Xiang Chen*, Jiaquan Luo*, Zhanmin Zhang§, Shaoqing Chen§, Yong Shu*, Zhimin Han*, Kai Cao*
Oncology Research, Vol.25, No.2, pp. 267-275, 2017, DOI:10.3727/096504016X14732510786564
Abstract miRNAs play a pivotal role in the development and progression of osteosarcoma (OS). Previous studies indicated that miR-140 acts as a tumor suppressor in many cancers. However, its accurate expression and exact
function in OS cells remain unknown. Herein, we demonstrated the lower expression of miR-140 in 40 paired
OS tissues. Restoring miR-140 expression in OS cells had a marked effect on inhibiting cell proliferation and
invasion, inducing cell apoptosis in vitro, and suppressing tumor growth in vivo. Moreover, a bioinformatics
prediction indicated that the histone deacetylase 4 (HDAC4) is a target gene of miR-140 and More >
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